Nanotechnology-based cell-mediated delivery systems for cancer therapy and diagnosis

被引：25

作者：

Alimardani, Vahid ^{[1
,2
]}

Rahiminezhad, Zahra ^{[1
,2
]}

DehghanKhold, Mahvash ^{[1
,2
]}

Farahavar, Ghazal ^{[1
,2
]}

Jafari, Mahboobeh ^{[1
,2
]}

Abedi, Mehdi ^{[1
,2
]}

Moradi, Leila ^{[1
,2
]}

Niroumand, Uranous ^{[1
,2
]}

Ashfaq, Mohammad ^{[3
,4
]}

Abolmaali, Samira Sadat ^{[1
,6
]}

Yousefi, Gholamhossein ^{[5
,6
]}

机构：

[1] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut Nanotechnol, Shiraz, Iran

[2] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[3] Chandigarh Univ, Univ Ctr Res & Dev UCRD, Mohali 140413, Punjab, India

[4] Chandigarh Univ, Dept Biotechnol, Mohali 140413, Punjab, India

[5] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut, Shiraz, Iran

[6] Shiraz Univ Med Sci, Ctr Drug Delivery Nanotechnol, r, Shiaz, Iran

来源：

DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2023年 / 13卷 / 01期

关键词：

Cell-based drug delivery; Sperm-based drug delivery; Drug delivery; Cancer therapy; Cancer diagnosis; Cell-based delivery systems; Stem cell-based delivery systems; OUTER-MEMBRANE VESICLES; TARGETED DRUG-DELIVERY; RBC-DERIVED VESICLES; RED-BLOOD-CELLS; ERYTHROCYTE-MEMBRANE; STEM-CELLS; COATED NANOPARTICLES; TUMOR-CELLS; CAMOUFLAGED NANOPARTICLES; SILICA NANOPARTICLES;

D O I：

10.1007/s13346-022-01211-9

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The global prevalence of cancer is increasing, necessitating new additions to traditional treatments and diagnoses to address shortcomings such as ineffectiveness, complications, and high cost. In this context, nano and microparticulate carriers stand out due to their unique properties such as controlled release, higher bioavailability, and lower toxicity. Despite their popularity, they face several challenges including rapid liver uptake, low chemical stability in blood circulation, immunogenicity concerns, and acute adverse effects. Cell-mediated delivery systems are important topics to research because of their biocompatibility, biodegradability, prolonged delivery, high loading capacity, and targeted drug delivery capabilities. To date, a variety of cells including blood, immune, cancer, and stem cells, sperm, and bacteria have been combined with nanoparticles to develop efficient targeted cancer delivery or diagnosis systems. The review paper aimed to provide an overview of the potential applications of cell-based delivery systems in cancer therapy and diagnosis.

引用

页码：189 / 221

页数：33

共 223 条

[1] Polyacrylamide-b-copolypeptide hybrid copolymer as pH-responsive carrier for delivery of paclitaxel: Effects of copolymer composition on nanomicelles properties, loading efficiency and hemocompatibility [J].