First-in-human phase I study of givastomig, a novel Claudin 18.2/4-1BB bispecific antibody in advanced solid tumors

被引：1

作者：

Ku, G. ^{[1
]}

Shen, L. ^{[2
]}

Klempner, S. J. ^{[3
]}

Pan, H. ^{[4
]}

Kratz, J. ^{[5
]}

Liang, X. ^{[6
]}

Deng, Y. ^{[7
]}

Kim, S. ^{[8
]}

Wang, Z. ^{[9
]}

Feller, L. ^{[10
]}

Powderly, J. ^{[11
]}

Dayyani, F. ^{[12
]}

Schneider, R. E. ^{[13
]}

Girda, E. ^{[14
]}

Berlin, J. D. ^{[15
]}

Spencer, K. ^{[16
]}

Nguyen, M. T. ^{[17
]}

Wang, V. ^{[17
]}

Xu, C. ^{[17
]}

Zhu, A. ^{[18
]}

机构：

[1] MSKCC Mem Sloan Kettering Canc Ctr, Dept Med, Gastrointestinal Oncol Serv, New York, NY USA

[2] Peking Univ Canc Hosp & Inst, GI Oncol Dept, Beijing, Peoples R China

[3] MGH Massachusetts Gen Hosp, Med Oncol Dept, Boston, MA USA

[4] Zhejiang Univ, Sir Run Run Run Shaw Hosp, Med, Sch Med, Hangzhou, Zhejiang, Peoples R China

[5] Univ Wisconsin, Med, Sch Med & Publ Hlth Med Phys, Madison, WI USA

[6] HuBei Canc Hosp, Med Dept, Wuhan, Peoples R China

[7] Sun Yat Sen Univ, Affiliated Hosp 6, Med, Guangzhou, Guangdong, Peoples R China

[8] Univ Colorado, Med Oncol Dept, UCHlth Canc Care, Ctr Canc, Anschutz Med Campus, Aurora, CO USA

[9] China Med Univ, Med, Affiliated Hosp 1, Shenyang, Peoples R China

[10] Horizon BioAdvance, Med Oncol Dept, Lafayette, LA USA

[11] Carolina BioOncol Inst, Oncol, Huntersville, NC USA

[12] UCI Univ Calif Irvine, Med Dept, Hlth Manchester Pavil, Orange, CA USA

[13] Mary Crowley Canc Res Ctr, Med Oncol Dept, Dallas, TX USA

[14] Rutgers Canc Inst New Jersey, Med Oncol Dept, New Brunswick, NJ USA

[15] Vanderbilt Univ, Med Dept, Med Ctr, Preston Canc Res Bldg, Nashville, TN USA

[16] NYU, Med Dept, Langone Laura & Isaac Perlmutter Canc Ctr, New York, NY USA

[17] I Mab Biopharma, Res & Dev, San Diego, CA USA

[18] I Mab Biopharma Co Ltd Headquarter, Res & Dev, Shanghai, Peoples R China

来源：

ANNALS OF ONCOLOGY | 2023年 / 34卷

关键词：

D O I：

10.1016/j.annonc.2023.09.2178

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1039P

引用

页码：S631 / S631

页数：1

共 50 条

[41] Phase I First-in-Human Study of TRK-950, an IgG1 Antibody Specific to CAPRIN-1, in Patients with Advanced Solid Tumors [J].

Cassier, Philippe A. ;

Borad, Mitesh J. ;

Sharma, Sunil ;

Dubois, Bertrand ;

Caux, Christophe ;

Okano, Fumiyoshi ;

Von Hoff, Daniel D. ;

Blay, Jean-Yves .

CANCER RESEARCH COMMUNICATIONS, 2025, 5 (07) :1119-1128

[42] First-in-human (FIH) phase I study of RO7122290 (RO), a novel FAP-targeted 4-1BB agonist, administered as single agent and in combination with atezolizumab (ATZ) to patients with advanced solid tumours [J].

Melero, I. ;

Sanmamed, M. F. ;

Calvo, E. ;

Moreno, I. ;

Moreno, V. ;

Hernandez Guerrero, T. C. ;

Martinez-Garcia, M. ;

Rodriguez-Vida, A. ;

Tabernero, J. ;

Azaro Pedrazzoli, A. B. ;

Spanggaard, I. ;

Rohrberg, K. S. ;

Guarin, E. ;

Nueesch, E. ;

Chesne, E. ;

Ceppi, M. ;

Sweere, U. ;

McIntyre, C. ;

Lichtenegger, F. S. ;

Krieter, O. .

ANNALS OF ONCOLOGY, 2020, 31 :S707-S707

[43] Phase 1 study of SGN-BB228, an investigational CD228 x 4-1BB costimulatory antibody anticalin bispecific, in patients with advanced melanoma and other solid tumors (SGNBB228-001). [J].

Henry, Jason Timothy ;

Mehnert, Janice M. ;

Rudnicki, Erika ;

Pinelli, Juan ;

Daud, Adil .

JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)

[44] A First-in-Human Phase I Study of GC1118, a Novel Anti-Epidermal Growth Factor Receptor Antibody, in Patients with Advanced Solid Tumors [J].

Oh, Do-Youn ;

Lee, Keun-Wook ;

Han, Sae-Won ;

Kim, Jin Won ;

Shin, Jung-Won ;

Jo, Seong-Jin ;

Won, Jonghwa ;

Hahn, Seokyung ;

Lee, Howard ;

Kim, Woo Ho ;

Bang, Yung-Jue .

ONCOLOGIST, 2019, 24 (08) :1037-+

[45] Phase I, first-in-human study of futibatinib, a highly selective, irreversible FGFR1-4 inhibitor in patients with advanced solid tumors [J].

Bahleda, R. ;

Meric-Bernstam, F. ;

Goyal, L. ;

Tran, B. ;

He, Y. ;

Yamamiya, I ;

Benhadji, K. A. ;

Matos, I ;

Arkenau, H-T .

ANNALS OF ONCOLOGY, 2020, 31 (10) :1405-1412

[46] A First-in-Human Phase I Monotherapy Study of RG7212 (R), a Novel Monoclonal Antibody Targeting TWEAK Signaling in Patients with Advanced Solid Tumors [J].

Lassen, U. ;

Schellens, J. H. M. ;

Siu, L. L. ;

Jonker, D. J. ;

Sorensen, M. ;

Jarutat, T. ;

Wang, K. ;

Gehoe, D. ;

DeMario, M. ;

Goss, G. .

EUROPEAN JOURNAL OF CANCER, 2012, 48 :12-12

[47] A phase 1, dose escalation/dose-expansion study of QLF31907, a bispecific antibody (BsAb) targeting PD-L1 and 4-1BB, in patients with advanced solid tumors and lymphoma [J].

Lin, Tongyu ;

Liu, Bin ;

Pu, Xingxiang ;

Wu, Lin ;

Du, Xiaobo ;

Mo, Ning ;

Song, Zhengbo ;

Zhou, Liwei ;

Duan, Xianlin ;

Zhu, Yanan ;

Kang, Xiaoyan .

JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)

[48] First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors [J].

Shitara, Kohei ;

Uehai, Satoshi ;

Shichino, Shigeyuki ;

Aoki, Hiroyasu ;

Ogiwara, Haru ;

Nakatsura, Tetsuya ;

Suzuki, Toshihiro ;

Shimomura, Manami ;

Yoshikawa, Toshiaki ;

Shoda, Kayoko ;

Kitano, Shigehisa ;

Yamashita, Makiko ;

Nakayama, Takayuki ;

Sato, Akihiro ;

Kuroda, Sakiko ;

Wakabayashi, Masashi ;

Nomura, Shogo ;

Yokochi, Shoji ;

Ito, Satoru ;

Matsushima, Kouji ;

Doi, Toshihiko .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7 :195

[49] A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors [J].

Teixeira, Luis ;

Medioni, Jacques ;

Garibal, Julie ;

Adotevi, Olivier ;

Doucet, Ludovic ;

Durey, Marie-Agnes Dragon ;

Ghrieb, Zineb ;

Kiladjian, Jean-Jacques ;

Brizard, Mara ;

Laheurte, Caroline ;

Wehbe, Maria ;

Pliquet, Elodie ;

Escande, Marie ;

Defrance, Remy ;

Culine, Stephane ;

Oudard, Stephane ;

Wain-Hobson, Simon ;

Doppler, Valerie ;

Huet, Thierry ;

Langlade-Demoyen, Pierre .

CLINICAL CANCER RESEARCH, 2020, 26 (03) :588-597

[50] First-in-human dose escalation and expansion study of SYSA1801, an antibody-drug conjugate targeting claudin 18.2 in patients with resistant/refractory solid tumors [J].

Wang, Yakun ;

Gong, Jifang ;

Lin, Rongbo ;

Zhao, Shen ;

Wang, Jufeng ;

Wang, Qianli ;

Zhang, Yanqiao ;

Su, Dan ;

Zhang, Jingdong ;

Dong, Qian ;

Lin, Ling ;

Tian, Wen ;

Chen, Ying ;

Yang, Yang ;

Zhang, Xueyuan ;

Wan, Xuechao ;

Gao, Jinfeng ;

An, Na ;

Jansen, Valerie Malyvanh ;

Shen, Lin .

JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)

← 1 2 3 4 5 →