First-in-human phase I study of givastomig, a novel Claudin 18.2/4-1BB bispecific antibody in advanced solid tumors

被引：1

作者：

Ku, G. ^{[1
]}

Shen, L. ^{[2
]}

Klempner, S. J. ^{[3
]}

Pan, H. ^{[4
]}

Kratz, J. ^{[5
]}

Liang, X. ^{[6
]}

Deng, Y. ^{[7
]}

Kim, S. ^{[8
]}

Wang, Z. ^{[9
]}

Feller, L. ^{[10
]}

Powderly, J. ^{[11
]}

Dayyani, F. ^{[12
]}

Schneider, R. E. ^{[13
]}

Girda, E. ^{[14
]}

Berlin, J. D. ^{[15
]}

Spencer, K. ^{[16
]}

Nguyen, M. T. ^{[17
]}

Wang, V. ^{[17
]}

Xu, C. ^{[17
]}

Zhu, A. ^{[18
]}

机构：

[1] MSKCC Mem Sloan Kettering Canc Ctr, Dept Med, Gastrointestinal Oncol Serv, New York, NY USA

[2] Peking Univ Canc Hosp & Inst, GI Oncol Dept, Beijing, Peoples R China

[3] MGH Massachusetts Gen Hosp, Med Oncol Dept, Boston, MA USA

[4] Zhejiang Univ, Sir Run Run Run Shaw Hosp, Med, Sch Med, Hangzhou, Zhejiang, Peoples R China

[5] Univ Wisconsin, Med, Sch Med & Publ Hlth Med Phys, Madison, WI USA

[6] HuBei Canc Hosp, Med Dept, Wuhan, Peoples R China

[7] Sun Yat Sen Univ, Affiliated Hosp 6, Med, Guangzhou, Guangdong, Peoples R China

[8] Univ Colorado, Med Oncol Dept, UCHlth Canc Care, Ctr Canc, Anschutz Med Campus, Aurora, CO USA

[9] China Med Univ, Med, Affiliated Hosp 1, Shenyang, Peoples R China

[10] Horizon BioAdvance, Med Oncol Dept, Lafayette, LA USA

[11] Carolina BioOncol Inst, Oncol, Huntersville, NC USA

[12] UCI Univ Calif Irvine, Med Dept, Hlth Manchester Pavil, Orange, CA USA

[13] Mary Crowley Canc Res Ctr, Med Oncol Dept, Dallas, TX USA

[14] Rutgers Canc Inst New Jersey, Med Oncol Dept, New Brunswick, NJ USA

[15] Vanderbilt Univ, Med Dept, Med Ctr, Preston Canc Res Bldg, Nashville, TN USA

[16] NYU, Med Dept, Langone Laura & Isaac Perlmutter Canc Ctr, New York, NY USA

[17] I Mab Biopharma, Res & Dev, San Diego, CA USA

[18] I Mab Biopharma Co Ltd Headquarter, Res & Dev, Shanghai, Peoples R China

来源：

ANNALS OF ONCOLOGY | 2023年 / 34卷

关键词：

D O I：

10.1016/j.annonc.2023.09.2178

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1039P

引用

页码：S631 / S631

页数：1

共 50 条

[21] Safety and Pharmacokinetic Assessment of the FIC CLDN18.2/4-1BB Bispecific Antibody in Rhesus Monkeys [J].

Wang, Jing ;

Dong, Tiantian ;

Gong, Xinjiang ;

Li, Deli ;

Sun, Joanne ;

Luo, Yi ;

Wu, Huazhang .

INTERNATIONAL JOURNAL OF TOXICOLOGY, 2024, 43 (03) :291-300

[22] Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors [J].

Muik, Alexander ;

Garralda, Elena ;

Altintas, Isil ;

Gieseke, Friederike ;

Geva, Ravit ;

Ben-Ami, Eytan ;

Maurice-Dror, Corinne ;

Calvo, Emiliano ;

LoRusso, Patricia M. ;

Alonso, Guzman ;

Rodriguez-Ruiz, Maria E. ;

Schoedel, Kristina B. ;

Blum, Jordan M. ;

Sanger, Bianca ;

Salcedo, Theodora W. ;

Burm, Saskia M. ;

Stanganello, Eliana ;

Verzijl, Dennis ;

Vascotto, Fulvia ;

Sette, Angelica ;

Quinkhardt, Juliane ;

Plantinga, Theo S. ;

Toker, Aras ;

van den Brink, Edward N. ;

Fereshteh, Mark ;

Diken, Mustafa ;

Satijn, David ;

Kreiter, Sebastian ;

Breij, Esther C. W. ;

Bajaj, Gaurav ;

Lagkadinou, Eleni ;

Sasser, Kate ;

Tureci, Ozlem ;

Forssmann, Ulf ;

Ahmadi, Tahamtan ;

Sahin, Ugur ;

Jure-Kunkel, Maria ;

Melero, Ignacio .

CANCER DISCOVERY, 2022, 12 (05) :1248-1265

[23] A First-in-Human Phase I Study of MORAb-004, a Monoclonal Antibody to Endosialin in Patients with Advanced Solid Tumors [J].

Diaz, Luis A., Jr. ;

Coughlin, Christina M. ;

Weil, Susan C. ;

Fishel, Jean ;

Gounder, Mrinal M. ;

Lawrence, Susan ;

Azad, Nilofer ;

O'Shannessy, Daniel J. ;

Grasso, Luigi ;

Wustner, Jason ;

Ebel, Wolfgang ;

Carvajal, Richard D. .

CLINICAL CANCER RESEARCH, 2015, 21 (06) :1281-1288

[24] A first-in-human phase I study of the anti-PD-1 antibody PDR001 in patients with advanced solid tumors [J].

Naing, Aung ;

Gelderblom, Hans ;

Gainor, Justin F. ;

Forde, Patrick M. ;

Butler, Marcus ;

Lin, Chia-Chi ;

Sharma, Sunil ;

de Olza, Maria Ochoa ;

Schellens, Jan H. M. ;

Soria, Jean-Charles ;

Taylor, Matthew H. ;

Silva, Antonio P. ;

Li, Zhonggai ;

Bilic, Sanela ;

Cameron, Scott ;

Infante, Jeffrey R. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)

[25] Initial findings from a first-in-human, multicenter, open-label study of ATOR-1017, a 4-1BB antibody, in patients with advanced solid malignancies [J].

Ullenhag, Gustav J. ;

Carneiro, Ana ;

Smith, Karin Enell ;

Schultz, Lena ;

Ambarkhane, Sumeet Vijay ;

Landstrom, Tova ;

Yachnin, Jeffrey .

JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)

[26] First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors [J].

Elena Elez ;

Carlos Gomez-Roca ;

Arturo Soto Matos-Pita ;

Guillem Argiles ;

Thibaud Valentin ;

Cinthya Coronado ;

Jorge Iglesias ;

Teresa Macarulla ;

Sarah Betrian ;

Salvador Fudio ;

Katrin Zaragoza ;

Josep Tabernero ;

Jean-Pierre Delord .

Investigational New Drugs, 2019, 37 :674-683

[27] First-in-human phase I study of the microtubule inhibitor plocabulin in patients with advanced solid tumors [J].

Elez, Elena ;

Gomez-Roca, Carlos ;

Soto Matos-Pita, Arturo ;

Argiles, Guillem ;

Valentin, Thibaud ;

Coronado, Cinthya ;

Iglesias, Jorge ;

Macarulla, Teresa ;

Betrian, Sarah ;

Fudio, Salvador ;

Zaragoza, Katrin ;

Tabernero, Josep ;

Delord, Jean-Pierre .

INVESTIGATIONAL NEW DRUGS, 2019, 37 (04) :674-683

[28] A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors [J].

Tabernero, Josep ;

Dirix, Luc ;

Schoffski, Patrick ;

Cervantes, Andres ;

Antonio Lopez-Martin, Jose ;

Capdevila, Jaume ;

van Beijsterveldt, Ludy ;

Platero, Suso ;

Hall, Brett ;

Yuan, Zhilong ;

Knoblauch, Roland ;

Zhuang, Sen Hong .

CLINICAL CANCER RESEARCH, 2011, 17 (19) :6313-6321

[29] Preliminary phase I results from a first-in-human study of EMB-02, a PD-1xLAG-3 bispecific antibody, in patients (pts) with advanced solid tumors [J].

Day, D. ;

Ganju, V. ;

Chung, K. ;

Si, L. ;

Mao, L. ;

Aghmesheh, M. ;

Hoyer, R. ;

Brewin, K. ;

Zeng, S. ;

Lu, Q. ;

Jiang, C. ;

Ren, F. ;

Wu, X. ;

Guo, J. .

ANNALS OF ONCOLOGY, 2023, 34 :S625-S625

[30] MEDI5752, a novel PD-1/CTLA-4 bispecific checkpoint inhibitor for advanced solid tumors: First-in-human study [J].

Tran, Ben ;

Voskoboynik, Mark ;

Kim, Sang-We ;

Lemech, Charlotte ;

Carcereny, Enric ;

Rha, Sun Young ;

Ahn, Myung-Ju ;

Felip, Enriqueta ;

Lee, Ki H. ;

Alvarez, Eduardo C. ;

Yang, James Chih-Hsin ;

Ascierto, Paolo A. ;

Pulla, Mariano P. ;

Freeman, Dan ;

Song, Xuyang ;

Gainer, Shelby D. ;

Mitchell, Patrick ;

Achour, Ikbel ;

Subramaniam, Deepa S. ;

Im, Seock-Ah .

CANCER RESEARCH, 2022, 82 (12)

← 1 2 3 4 5 →