A chloroplast proteostasis factor prevents aggregation of a human disease-related protein

被引：0
|
作者：
Vilchez, David [1 ]
Llamas, Ernesto [1 ]
机构：
[1] Univ Cologne, Cologne, Germany
来源：
NATURE AGING | 2023年 / 3卷 / 11期
关键词：
D O I：
10.1038/s43587-023-00503-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Plants have an additional organelle to animals (the chloroplast), which means that they have a greater repertoire of protein homeostasis (proteostasis) mechanisms. We find that chloroplast proteostasis components prevent aggregation of a pathogenic fragment of human huntingtin expressed in plants, which reveals a potential avenue for therapeutic intervention in human proteinopathies.
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收藏
页码：1323 / 1324
页数：2
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