Nanocarriers for photodynamic-gene therapy

被引：5

作者：

de Santana, Willian Max O. S. ^{[1
]}

Surur, Amanda Koberstain ^{[2
]}

Momesso, Vinicius Medeiros ^{[2
]}

Lopes, Pedro Monteiro ^{[2
]}

Santilli, Celso, V ^{[1
]}

Fontana, Carla Raquel ^{[2
]}

机构：

[1] Sao Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil

[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, Brazil

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2023年 / 43卷

关键词：

Photodynamic therapy; Gene therapy; Combination therapy; Nanoparticles; Nonviral vectors; Anticancer; STIMULI-RESPONSIVE NANOCARRIERS; DRUG-DELIVERY; CELLULAR UPTAKE; CANCER-THERAPY; POLY(GAMMA-GLUTAMIC ACID); TUMOR MICROENVIRONMENT; NANOPARTICLE DELIVERY; MOLECULAR-WEIGHT; TRANSFECTION; EFFICIENCY;

D O I：

10.1016/j.pdpdt.2023.103644

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The use of nanotechnology in medicine has important potential applications, including in anticancer strategies. Nanomedicine has made it possible to overcome the limitations of conventional monotherapies, in addition to improving therapeutic results by means of synergistic or cumulative effects. A highlight is the combination of gene therapy (GT) and photodynamic therapy (PDT), which are alternative anticancer approaches that have attracted attention in the last decade. In this review, strategies involving the combination of PDT and GT will be discussed, together with the role of nanocarriers (nonviral vectors) in this synergistic therapeutic approach, including aspects related to the design of nanomaterials, responsiveness, the interaction of the nanomaterial with the biological environment, and anticancer performance in studies in vitro and in vivo.

引用

页数：30

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