High oxygen-modified packaging (HiOx-MAP) mediates HIF-1α regulation of tenderness changes during postmortem aging of yak meat

被引：9
作者：
Xin, Ke-qi [1 ]
Tian, Kai [1 ]
Yu, Qun-li [1 ]
Han, Ling [1 ]
机构：
[1] Gansu Agr Univ, Coll Food Sci & Engn, Lanzhou, Peoples R China
来源：
FOOD CHEMISTRY-X | 2023年 / 17卷
基金：
中国国家自然科学基金;
关键词：
Tenderization; Apoptosis; High -oxygen packaging; Yak; HIF-1-ALPHA-MEDIATED UP-REGULATION; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; CA2+ RELEASE; APOPTOSIS; HYPOXIA; ROLES; MUSCLE; MECHANISM;
D O I：
10.1016/j.fochx.2023.100573
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In the present study, we studied the effect of high oxygen-modified packaging (HiOx-MAP) on yak meat tenderness and the underlying mechanism. HiOx-MAP significantly increased the myofibril fragmentation index (MFI) of yak meat. In addition, western blotting showed that the expression of hypoxia-inducible factor (HIF-1 & alpha;) and ryanodine receptors (RyR) in the HiOx-MAP group was reduced. HiOx-MAP increased the activity of sarcoplasmic reticulum calcium-ATPase (SERCA). The energy disperse spectroscopy (EDS) mapping showed gradually reduced calcium distribution in the treated endoplasmic reticulum. Furthermore, HiOx-MAP treatment increased the caspase-3 activity and the apoptosis rate. The activity of calmodulin protein (CaMKK & beta;) and AMPactivated protein kinase (AMPK) was down-regulated leading to apoptosis. These results indicated that HiOxMAP promoted apoptosis during postmortem aging to improve the tenderization of meat.
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页数：15
相关论文
共 52 条
[1]  
AMSA, 2012, AMSA MEAT COLOR MEAS, V1820
[2]   Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells [J].
Cardozo, AK ;
Ortis, F ;
Storling, J ;
Feng, YM ;
Rasschaert, J ;
Tonnesen, M ;
Van Eylen, F ;
Mandrup-Poulsen, T ;
Herchuez, A ;
Eizirik, DL .
DIABETES, 2005, 54 (02) :452-461
[3]   Effects of ultrasonic processing on caspase-3, calpain expression and myofibrillar structure of chicken during post-mortem ageing [J].
Chen, Lin ;
Feng, Xian-Chao ;
Zhang, Ying-yang ;
Liu, Xue-bo ;
Zhang, Wan-gang ;
Li, Chun-bao ;
Ullah, Niamat ;
Xu, Xing-lian ;
Zhou, Guang-hong .
FOOD CHEMISTRY, 2015, 177 :280-287
[4]   Double staining immunohistochemistry [J].
Chen, Xiao ;
Cho, Dan-Bi ;
Yang, Ping-Chang .
NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES, 2010, 2 (05) :241-245
[5]   Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia - HIF-1-independent mechanisms [J].
Dong, Z ;
Venkatachalam, MA ;
Wang, JZ ;
Patel, Y ;
Saikumar, P ;
Semenza, GL ;
Force, T ;
Nishiyama, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (22) :18702-18709
[6]   The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator [J].
Faubert, Brandon ;
Vincent, Emma E. ;
Poffenberger, Maya C. ;
Jones, Russell G. .
CANCER LETTERS, 2015, 356 (02) :165-170
[7]   Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death [J].
Festjens, N ;
van Gurp, M ;
van Loo, G ;
Saelens, X ;
Vandenabeele, P .
ACTA HAEMATOLOGICA, 2003, 111 (1-2) :7-27
[8]   HIF-1-regulated glucose metabolism a key to apoptosis resistance? [J].
Fulda, Simone ;
Debatin, Klaus-Michael .
CELL CYCLE, 2007, 6 (07) :790-792
[9]   Study on the effect of CaMKKβ-mediated AMPK activation on the glycolysis and the quality of different altitude postmortem bovines longissimus muscle [J].
Gao, Yongfang ;
Yang, Yayuan ;
Han, Ling ;
Yu, Qunli ;
Song, Rende ;
Han, Mingshan ;
Shi, Hongmei ;
He, Long .
JOURNAL OF FOOD BIOCHEMISTRY, 2019, 43 (11)
[10]   The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis [J].
Greijer, AE ;
van der Wall, E .
JOURNAL OF CLINICAL PATHOLOGY, 2004, 57 (10) :1009-1014
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