Impact of Advanced Hybrid Closed Loop on Youth With High-Risk Type 1 Diabetes Using Multiple Daily Injections

被引：21

作者：

Boucsein, Alisa ^{[1
]}

Watson, Antony S. ^{[2
]}

Frewen, Carla M. ^{[1
]}

Sanders, Olivia J. ^{[2
]}

Haszard, Jillian J. ^{[3
]}

Jones, Shirley D. ^{[1
]}

Milford-Hughes, Philippa J. ^{[1
]}

de Bock, Martin I. ^{[2
,4
]}

Wheeler, Benjamin J. ^{[1
,5
]}

机构：

[1] Univ Otago, Dept Womens & Childrens Hlth, Dunedin, New Zealand

[2] Univ Otago, Dept Paediat, Christchurch, New Zealand

[3] Univ Otago, Biostat Ctr, Dunedin, New Zealand

[4] Te Whatu Ora Hlth New Zealand, Christchurch, New Zealand

[5] Te Whatu Ora Hlth New Zealand, Dunedin, New Zealand

来源：

DIABETES CARE | 2023年 / 46卷 / 03期

关键词：

ADULTS;

D O I：

10.2337/dc22-1971

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE To evaluate glycemic outcomes in youth (aged 13-25 years) with type 1 diabetes and high-risk glycemic control (HbA(1c) >= 8.5% [69 mmol/mol]) on multiple daily injection (MDI) therapy after transitioning to advanced hybrid closed loop (AHCL) therapy. RESEARCH DESIGN AND METHODS This prospective, 3-month, single-arm, dual-center study enrolled 20 participants, and all completed the study. RESULTS HbA(1c) decreased from 10.5 2.1% (91.2 +/- 22.8 mmol/mol) at baseline to 7.6 +/- 1.1% (59.7 +/- 11.9 mmol/mol), and time spent in target range 70-180 mg/dL (3.9-10.0 mmol/L) increased from 27.6 +/- 13.2% at baseline to 66.5 +/- 9.8% after 3 months of AHCL. Two episodes of diabetic ketoacidosis attributed to infusion set failure occurred. CONCLUSIONS AHCL has the potential to improve suboptimal glycemia in youth with type 1 diabetes previously on MDI therapy.

引用

页码：628 / 632

页数：6

共 20 条

[1] 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021
不详
[J]. DIABETES CARE, 2021, 44 : S15 - S33
[2] Atkinson J., 2019, NZDEP2018 INDEX DEPR
[3] Bergenstal RM, 2021, LANCET, V397, P208, DOI 10.1016/S0140-6736(20)32514-9
[4] Six months of hybrid closed loop in the real-world: An evaluation of children and young adults using the 670G system
Berget, Cari
Messer, Laurel H.
Vigers, Tim
Frohnert, Brigitte I.
Pyle, Laura
Wadwa, R. Paul
Driscoll, Kimberly A.
Forlenza, Gregory P.
[J]. PEDIATRIC DIABETES, 2020, 21 (02) : 310 - 318
[5] The artificial pancreas
Boughton, Charlotte K.
Hovorka, Roman
[J]. CURRENT OPINION IN ORGAN TRANSPLANTATION, 2020, 25 (04) : 336 - 342
[6] Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes
Brown, S. A.
Kovatchev, B. P.
Raghinaru, D.
Lum, J. W.
Buckingham, B. A.
Kudva, Y. C.
Laffel, L. M.
Levy, C. J.
Pinsker, J. E.
Wadwa, R. P.
Dassau, E.
Doyle, F. J., III
Anderson, S. M.
Church, M. M.
Dadlani, V
Ekhlaspour, L.
Forlenza, G. P.
Isganaitis, E.
Lam, D. W.
Kollman, C.
Beck, R. W.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (18) : 1707 - 1717
[7] Open-Source Automated Insulin Delivery in Type 1 Diabetes
Burnside, Mercedes J.
Lewis, Dana M.
Crocket, Hamish R.
Meier, Renee A.
Williman, Jonathan A.
Sanders, Olivia J.
Jefferies, Craig A.
Faherty, Ann M.
Paul, Ryan G.
Lever, Claire S.
Price, Sarah K. J.
Frewen, Carla M.
Jones, Shirley D.
Gunn, Tim C.
Lampey, Christina
Wheeler, Benjamin J.
de Bock, Martin, I
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (10) : 869 - 881
[8] Choudhary P, 2022, LANCET DIABETES ENDO, V10, P720, DOI [10.1016/S2213-8587(22)00212.1, 10.1016/S2213-8587(22)00212-1]
[9] Improved Glycemic Outcomes With Medtronic MiniMed Advanced Hybrid Closed-Loop Delivery: Results From a Randomized Crossover Trial Comparing Automated Insulin Delivery With Predictive Low Glucose Suspend in People With Type 1 Diabetes
Collyns, Olivia J.
Meier, Renee A.
Betts, Zara L.
Chan, Denis S. H.
Frampton, Chris
Frewen, Carla M.
Hewapathirana, Niranjala M.
Jones, Shirley D.
Roy, Anirban
Grosman, Benyamin
Kurtz, Natalie
Shin, John
Vigersky, Robert A.
Wheeler, Benjamin J.
de Bock, Martin I.
[J]. DIABETES CARE, 2021, 44 (04) : 969 - 975
[10] A Review of Adolescent Adherence in Type 1 Diabetes and the Untapped Potential of Diabetes Providers to Improve Outcomes
Datye, Karishma A.
Moore, Daniel J.
Russell, William E.
Jaser, Sarah S.
[J]. CURRENT DIABETES REPORTS, 2015, 15 (08)

← 1 2 →