Impact of Advanced Hybrid Closed Loop on Youth With High-Risk Type 1 Diabetes Using Multiple Daily Injections

被引：24

作者：

Boucsein, Alisa ^{[1
]}

Watson, Antony S. ^{[2
]}

Frewen, Carla M. ^{[1
]}

Sanders, Olivia J. ^{[2
]}

Haszard, Jillian J. ^{[3
]}

Jones, Shirley D. ^{[1
]}

Milford-Hughes, Philippa J. ^{[1
]}

de Bock, Martin I. ^{[2
,4
]}

Wheeler, Benjamin J. ^{[1
,5
]}

机构：

[1] Univ Otago, Dept Womens & Childrens Hlth, Dunedin, New Zealand

[2] Univ Otago, Dept Paediat, Christchurch, New Zealand

[3] Univ Otago, Biostat Ctr, Dunedin, New Zealand

[4] Te Whatu Ora Hlth New Zealand, Christchurch, New Zealand

[5] Te Whatu Ora Hlth New Zealand, Dunedin, New Zealand

来源：

DIABETES CARE | 2023年 / 46卷 / 03期

关键词：

ADULTS;

D O I：

10.2337/dc22-1971

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE To evaluate glycemic outcomes in youth (aged 13-25 years) with type 1 diabetes and high-risk glycemic control (HbA(1c) >= 8.5% [69 mmol/mol]) on multiple daily injection (MDI) therapy after transitioning to advanced hybrid closed loop (AHCL) therapy. RESEARCH DESIGN AND METHODS This prospective, 3-month, single-arm, dual-center study enrolled 20 participants, and all completed the study. RESULTS HbA(1c) decreased from 10.5 2.1% (91.2 +/- 22.8 mmol/mol) at baseline to 7.6 +/- 1.1% (59.7 +/- 11.9 mmol/mol), and time spent in target range 70-180 mg/dL (3.9-10.0 mmol/L) increased from 27.6 +/- 13.2% at baseline to 66.5 +/- 9.8% after 3 months of AHCL. Two episodes of diabetic ketoacidosis attributed to infusion set failure occurred. CONCLUSIONS AHCL has the potential to improve suboptimal glycemia in youth with type 1 diabetes previously on MDI therapy.

引用

页码：628 / 632

页数：6

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