Effect of Intravenous Thrombolytic Dose of Alteplase on Long-Term Prognosis in Patients with Acute Ischemic Stroke

被引:3
|
作者
Zhai, Mingfeng [1 ]
Cao, Shugang [2 ]
Yang, Jinwei [3 ]
Cao, Xiaoyan [3 ,4 ]
Dong, Zhong [3 ,4 ]
Liu, Wanyin [1 ]
Fu, Yongzhan [1 ]
Guan, Qiyue [1 ]
Wang, Yu [3 ,4 ]
Liu, Hongbo [5 ]
机构
[1] Anhui Med Univ, Affiliated Fuyang Peoples Hosp, Fuyang Peoples Hosp, Dept Neurol, Fuyang, Peoples R China
[2] Anhui Med Univ, Affiliated Hefei Hosp, Peoples Hosp Hefei 2, Dept Neurol, Hefei, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, Hefei 230022, Peoples R China
[4] Anhui Publ Hlth Clin Ctr, Hefei, Peoples R China
[5] Anhui Med Univ, Affiliated Fuyang Peoples Hosp, Fuyang Peoples Hosp, Dept Emergency, Fuyang 236000, Peoples R China
基金
中国国家自然科学基金;
关键词
Ischemic stroke; Thrombolysis; Alteplase; Recurrence; Prognosis; FUNCTIONAL STATUS; TRIAL; MULTICENTER; RECURRENCE; SURVIVAL; OUTCOMES; THERAPY; IMPACT; COHORT; CARE;
D O I
10.1007/s40120-023-00488-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
IntroductionThis study aimed to investigate the long-term prognostic effects of different alteplase doses on patients with acute ischemic stroke (AIS).MethodsIn this cohort study, we enrolled 501 patients with AIS treated with intravenous thrombolysis with alteplase, with the primary endpoint event of recurrence of ischemic stroke and the secondary endpoint event of death. The effects of different doses of alteplase on recurrence of ischemic stroke and death were analyzed using a Cox proportional risk model.ResultsAmong 501 patients with AIS treated with thrombolysis, 295 patients (58.9%) and 206 patients (41.1%) were treated with low-dose and standard-dose alteplase, respectively. During the study period, 61 patients (12.2%) had a confirmed recurrence of ischemic stroke. Multivariate Cox proportional risk analysis showed that standard-dose alteplase thrombolysis (HR 0.511, 95% CI 0.288-0.905, P = 0.021) was significantly associated with a reduced risk of long-term recurrence of AIS, whereas atrial fibrillation was associated with an increased risk of long-term recurrence of AIS. Thirty-nine (7.8%) patients died during the study period. Multivariate Cox proportional risk analysis showed that age, baseline National Institutes of Health Stroke Scale (NIHSS) score, and symptomatic steno-occlusion were associated with an increased long-term risk of death from AIS. The alteplase dose was not associated with the risk of death from AIS.ConclusionsStandard-dose alteplase treatment reduced the risk of long-term recurrence of AIS after hospital discharge and the alteplase dose was not associated with the long-term risk of death from AIS.
引用
收藏
页码:1105 / 1118
页数:14
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