Biofilm and wound healing: from bench to bedside

被引:53
作者
Goswami, Aakansha Giri [1 ]
Basu, Somprakas [1 ]
Banerjee, Tuhina [2 ]
Shukla, Vijay Kumar [2 ]
机构
[1] All India Inst Med Sci, Rishikesh 249203, India
[2] Banaras Hindu Univ, Varanasi, India
关键词
Biofilm; Bacteria; Wound healing; Quorum sensing; Debridement; HYPERBARIC-OXYGEN THERAPY; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANCE; ANTIBACTERIAL ACTIVITY; MULTISPECIES BIOFILMS; SILVER NANOPARTICLES; BINDING-PROTEIN; GENE-EXPRESSION; HOST RESPONSES;
D O I
10.1186/s40001-023-01121-7
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The bubbling community of microorganisms, consisting of diverse colonies encased in a self-produced protective matrix and playing an essential role in the persistence of infection and antimicrobial resistance, is often referred to as a biofilm. Although apparently indolent, the biofilm involves not only inanimate surfaces but also living tissue, making it truly ubiquitous. The mechanism of biofilm formation, its growth, and the development of resistance are ever-intriguing subjects and are yet to be completely deciphered. Although an abundance of studies in recent years has focused on the various ways to create potential anti-biofilm and antimicrobial therapeutics, a dearth of a clear standard of clinical practice remains, and therefore, there is essentially a need for translating laboratory research to novel bedside anti-biofilm strategies that can provide a better clinical outcome. Of significance, biofilm is responsible for faulty wound healing and wound chronicity. The experimental studies report the prevalence of biofilm in chronic wounds anywhere between 20 and 100%, which makes it a topic of significant concern in wound healing. The ongoing scientific endeavor to comprehensively understand the mechanism of biofilm interaction with wounds and generate standardized anti-biofilm measures which are reproducible in the clinical setting is the challenge of the hour. In this context of "more needs to be done", we aim to explore various effective and clinically meaningful methods currently available for biofilm management and how these tools can be translated into safe clinical practice.
引用
收藏
页数:18
相关论文
共 50 条
[41]   Therapeutic advances in wound healing [J].
Oliveira, Andre ;
Simoes, Sandra ;
Ascenso, Andreia ;
Reis, Catarina Pinto .
JOURNAL OF DERMATOLOGICAL TREATMENT, 2022, 33 (01) :2-22
[42]   Role of infection in wound healing [J].
Hussain, Malik Asif ;
Huygens, Flavia .
BANGLADESH JOURNAL OF MEDICAL SCIENCE, 2020, 19 (04) :598-602
[43]   Mycosynthesis of Nanobiomaterials and Their Wound Healing, Antimicrobial, and Biofilm Inhibitory Activities [J].
Sunday Adewale Akintelu ;
Abel Kolawole Oyebamiji ;
Seyifunmi Charles Olugbeko ;
Deborah Omowunmi Afolabi ;
Dennisha Magdalene David ;
Lazarus Obed Livingstone Banda ;
Mary Oluwatosin Kaka ;
Jonathan O. babalola .
Plasmonics, 2023, 18 :1403-1427
[44]   Bacteria and Antibiotics in Wound Healing [J].
Caldwell, Michael D. .
SURGICAL CLINICS OF NORTH AMERICA, 2020, 100 (04) :757-+
[45]   Effectiveness of biofilm-based wound care system on wound healing in chronic wounds [J].
Mori, Yukie ;
Nakagami, Gojiro ;
Kitamura, Aya ;
Minematsu, Takeo ;
Kinoshita, Mikio ;
Suga, Hiraku ;
Kurita, Masakazu ;
Hayashi, Chieko ;
Kawasaki, Akiko ;
Sanada, Hiromi .
WOUND REPAIR AND REGENERATION, 2019, 27 (05) :540-547
[46]   Biofilm Production by Critical Antibiotic-Resistant Pathogens from an Equine Wound [J].
Afonso, Ana C. ;
Sousa, Mariana ;
Pinto, Ana Rita ;
Cotovio, Mario ;
Simoes, Manuel ;
Saavedra, Maria Jose .
ANIMALS, 2023, 13 (08)
[47]   Development of antibacterial pectin from Akebia trifoliata var. australis waste for accelerated wound healing [J].
Yu, Ningxiang ;
Wang, Xiaoya ;
Ning, Fangjian ;
Jiang, Chengjia ;
Li, Yanbin ;
Peng, Hailong ;
Xiong, Hua .
CARBOHYDRATE POLYMERS, 2019, 217 :58-68
[48]   Antibiotic heteroresistance in ESKAPE pathogens, from bench to bedside [J].
Roch, Melanie ;
Sierra, Roberto ;
Andrey, Diego O. .
CLINICAL MICROBIOLOGY AND INFECTION, 2023, 29 (03) :320-325
[49]   Antimicrobial resistance in Acinetobacter baumannii : From bench to bedside [J].
Lin, Ming-Feng ;
Lan, Chung-Yu .
WORLD JOURNAL OF CLINICAL CASES, 2014, 2 (12) :787-814
[50]   Antimicrobial resistance in Acinetobacter baumannii : From bench to bedside [J].
Ming-Feng Lin ;
Chung-Yu Lan .
World Journal of Clinical Cases, 2014, (12) :787-814