New insight in the cross-talk between microglia and schizophrenia: From the perspective of neurodevelopment

被引：8
作者：
Li, Jingjing [1 ,2 ,3 ]
Wang, Yu [4 ]
Yuan, Xiuxia [1 ,2 ,3 ]
Kang, Yulin [5 ]
Song, Xueqin [1 ,2 ,3 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China
[2] Henan Int Joint Lab Biol Psychiat, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Henan Psychiat Transformat Res Key Lab, Zhengzhou, Peoples R China
[4] Chongqing Med Univ, Coll Clin 1, Chongqing, Peoples R China
[5] Chinese Res Inst Environm Sci, Inst Environm Informat, Beijing, Peoples R China
来源：
FRONTIERS IN PSYCHIATRY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
schizophrenia; microglia; maternal immune activation; synaptic pruning; inflammation; PRENATAL IMMUNE ACTIVATION; 1ST-EPISODE PSYCHOSIS; BRAIN; DEFICITS; MODEL; EXPOSURE; MICE; INFLAMMATION; EXPRESSION; INDUCTION;
D O I：
10.3389/fpsyt.2023.1126632
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Characterized by psychotic symptoms, negative symptoms and cognitive deficits, schizophrenia had a catastrophic effect on patients and their families. Multifaceted reliable evidence indicated that schizophrenia is a neurodevelopmental disorder. Microglia, the immune cells in central nervous system, related to many neurodevelopmental diseases. Microglia could affect neuronal survival, neuronal death and synaptic plasticity during neurodevelopment. Anomalous microglia during neurodevelopment may be associated with schizophrenia. Therefore, a hypothesis proposes that the abnormal function of microglia leads to the occurrence of schizophrenia. Nowadays, accumulating experiments between microglia and schizophrenia could afford unparalleled probability to assess this hypothesis. Herein, this review summarizes the latest supporting evidence in order to shed light on the mystery of microglia in schizophrenia.
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页数：9
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