The LDL-C/Apo B predicts coronary atherosclerotic heart disease in non-diabetic patients without high LDL-C

被引:8
作者
Jung, Hae Won [1 ]
Ra, Moni [1 ]
Bae, Han Joon [1 ]
Hong, Seung-Pyo [1 ]
机构
[1] Daegu Catholic Univ, Dept Cardiol, Med Ctr, 33 Duryugongwonro 17 Gil, Daegu 42472, South Korea
关键词
apolipoprotein a1; apolipoprotein b; coronary atherosclerosis; lipoprotein (a); low-density lipoprotein cholesterol; APOLIPOPROTEIN-B; LIPOPROTEIN-CHOLESTEROL; MYOCARDIAL-INFARCTION; RISK;
D O I
10.1097/MD.0000000000032596
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The apolipoprotein B (Apo B), Apo B/A1 ratio, lipoprotein (a), and low-density lipoprotein cholesterol (LDL-C)/Apo B ratio are associated with coronary artery disease (CAD). However, the association between these parameters and CAD in non-diabetic patients without high LDL-C levels is unclear. Our goal was to assess which parameter was most strongly associated with CAD in non-diabetic patients without high LDL-C levels. This study included 487 non-diabetic patients with LDL-C < 130.0 mg/dL. All the patients underwent coronary computed tomographic angiography. We assessed the significance of each continuous atherogenic biomarker for CAD (incidence of coronary plaque and revascularization) without and after adjustment for standard risk factors. The LDL-C/Apo B ratio and lipoprotein (a) were significant risk factors for the incidence of coronary plaque on multivariate analysis after adjustment for standard risk factors. The LDL-C/Apo B ratio was significant for the incidence of revascularization in multivariate analysis after adjustment for standard risk factors. The degree of coronary calcification and plaque burden according to the tertile of LDL-C/Apo B showed significant differences between the groups. Our data indicate that LDL-C/Apo B ratio is the most predictive parameter for coronary atherosclerosis in non-diabetic patients without high LDL-C levels.
引用
收藏
页数:5
相关论文
共 29 条
  • [1] Risks of Incident Cardiovascular Disease Associated With Concomitant Elevations in Lipoprotein(a) and Low-Density Lipoprotein Cholesterol-The Framingham Heart Study
    Afshar, Mehdi
    Rong, Jian
    Zhan, Yang
    Chen, Hao Yu
    Engert, James C.
    Sniderman, Allan D.
    Larson, Martin G.
    Vasan, Ramachandran S.
    Thanassoulis, George
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (18):
  • [2] QUANTIFICATION OF CORONARY-ARTERY CALCIUM USING ULTRAFAST COMPUTED-TOMOGRAPHY
    AGATSTON, AS
    JANOWITZ, WR
    HILDNER, FJ
    ZUSMER, NR
    VIAMONTE, M
    DETRANO, R
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1990, 15 (04) : 827 - 832
  • [3] Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target
    Behbodikhah, Jennifer
    Ahmed, Saba
    Elyasi, Ailin
    Kasselman, Lora J.
    De Leon, Joshua
    Glass, Amy D.
    Reiss, Allison B.
    [J]. METABOLITES, 2021, 11 (10)
  • [4] Coronary calcification is associated with elevated serum lipoprotein (a) levels in asymptomatic men over the age of 45 years A cross-sectional study of the Korean national health checkup data
    Chung, Young Hak
    Lee, Byoung-Kwon
    Kwon, Hyuck Moon
    Min, Pil-Ki
    Choi, Eui-Young
    Yoon, Young Won
    Hong, Bum-Kee
    Rim, Se-Joong
    Kim, Jong-Youn
    [J]. MEDICINE, 2021, 100 (09) : E24962
  • [5] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    Cleeman, JI
    Grundy, SM
    Becker, D
    Clark, LT
    Cooper, RS
    Denke, MA
    Howard, WJ
    Hunninghake, DB
    Illingworth, DR
    Luepker, RV
    McBride, P
    McKenney, JM
    Pasternak, RC
    Stone, NJ
    Van Horn, L
    Brewer, HB
    Ernst, ND
    Gordon, D
    Levy, D
    Rifkind, B
    Rossouw, JE
    Savage, P
    Haffner, SM
    Orloff, DG
    Proschan, MA
    Schwartz, JS
    Sempos, CT
    Shero, ST
    Murray, EZ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19): : 2486 - 2497
  • [6] The LDL-C/ApoB ratio predicts major cardiovascular events in patients with established atherosclerotic cardiovascular disease
    Drexel, Heinz
    Larcher, Barbara
    Mader, Arthur
    Vonbank, Alexander
    Heinzle, Christine F.
    Moser, Berthold
    Zanolin-Purin, Daniela
    Saely, Christoph H.
    [J]. ATHEROSCLEROSIS, 2021, 329 : 44 - 49
  • [7] Duran EK, 2020, J AM COLL CARDIOL, V75, P2122, DOI 10.1016/j.jacc.2020.02.059
  • [8] Diabetes and cardiovascular disease - A statement for healthcare professionals from the American Heart Association
    Grundy, SM
    Benjamin, IJ
    Burke, GL
    Chait, A
    Eckel, RH
    Howard, BV
    Mitch, W
    Smith, SC
    Sowers, JR
    [J]. CIRCULATION, 1999, 100 (10) : 1134 - 1146
  • [9] Long-term outcomes in patients with normal coronary arteries, nonobstructive, or obstructive coronary artery disease on invasive coronary angiography
    Hanson, Christopher A.
    Lu, Edwin
    Ghumman, Saad S.
    Ouellette, Michelle L.
    Loffler, Adrian I.
    Beller, George A.
    Bourque, Jamieson M.
    [J]. CLINICAL CARDIOLOGY, 2021, 44 (09) : 1286 - 1295
  • [10] Measurement of small dense low-density lipoprotein particles
    Hirano, T
    Ito, Y
    Yoshino, G
    [J]. JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2005, 12 (02) : 67 - 72