Concise Review: Bioengineering of Limbal Stem Cell Niche

被引：0
|
作者：
Soleimani, Mohammad [1 ,2 ]
Cheraqpour, Kasra [1 ]
Koganti, Raghuram [2 ]
Baharnoori, Seyed Mahbod [2 ]
Djalilian, Ali R. [2 ]
机构：
[1] Univ Tehran Med Sci, Farabi Eye Hosp, Eye Res Ctr, Tehran 1336616351, Iran
[2] Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA
来源：
BIOENGINEERING-BASEL | 2023年 / 10卷 / 01期
关键词：
limbal stem cells; limbal stem cell deficiency; LSCD; limbal stem cell niche; limbal niche; bioengineering; niche restoration;
D O I：
10.3390/bioengineering10010111
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The corneal epithelium is composed of nonkeratinized stratified squamous cells and has a significant turnover rate. Limbal integrity is vital to maintain the clarity and avascularity of the cornea as well as regeneration of the corneal epithelium. Limbal epithelial stem cells (LESCs) are located in the basal epithelial layer of the limbus and preserve this homeostasis. Proper functioning of LESCs is dependent on a specific microenvironment, known as the limbal stem cell niche (LSCN). This structure is made up of various cells, an extracellular matrix (ECM), and signaling molecules. Different etiologies may damage the LSCN, leading to limbal stem cell deficiency (LSCD), which is characterized by conjunctivalization of the cornea. In this review, we first summarize the basics of the LSCN and then focus on current and emerging bioengineering strategies for LSCN restoration to combat LSCD.
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页数：18
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