Characterization of hitherto unknown Valsartan photodegradation impurities

被引：1
作者：
Kurzawa, Timon [1 ]
Fazzani, Salim [1 ]
Tempel, Rene [1 ]
Helmboldt, Hannes [1 ]
Bleschke, Christian [1 ]
Kohlmann, Andreas [1 ]
Hagenbach, Adelheid [2 ]
机构：
[1] LGC GmbH, Louis Pasteur Str 30, D-14943 Luckenwalde, Germany
[2] Free Univ Berlin, Inst Chem & Biochem, Fabeckstr 34-36, D-14195 Berlin, Germany
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1275卷
关键词：
Valsartan; Photodegradation; Potential impurities; DEGRADATION-PRODUCTS; AMINES; FORMYLATION; VALIDATION;
D O I：
10.1016/j.molstruc.2022.134599
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A detailed investigation of Valsartan's light-induced degradation is reported. Based on UPLC-HRMS studies of stressed solutions several degradation pathways are proposed. Some of the proposed structures were obtained by forced degradation experiments. Examination of analytical data including crystal structures allowed for structural revision of one literature-known degradant. In addition, irradiation under aero-bic conditions revealed further degradative pathways leading to two previously unknown decomposition products. Mechanistic considerations regarding their origin helped to identify structural weak points of Valsartan under the influence of light. (c) 2022 LGC Ltd Luckenwalde. Published by Elsevier B.V.
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页数：8
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