Recent Advances in Fluorescent Probes for Cancer Biomarker Detection

被引：17

作者：

Tian, Mingce ^{[1
,2
]}

Wu, Riliga ^{[1
]}

Xiang, Caihong ^{[3
]}

Niu, Guangle ^{[3
]}

Guan, Weijiang ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

[2] Beijing Inst Smart Energy, Beijing 102209, Peoples R China

[3] Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 100081, Peoples R China

来源：

MOLECULES | 2024年 / 29卷 / 05期

基金：

中国国家自然科学基金;

关键词：

cancer biomarkers; fluorescent probe; detection; biosensing; imaging; AGGREGATION-INDUCED EMISSION; STRATEGY; PH;

D O I：

10.3390/molecules29051168

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many important biological species have been identified as cancer biomarkers and are gradually becoming reliable targets for early diagnosis and late therapeutic evaluation of cancer. However, accurate quantitative detection of cancer biomarkers remains challenging due to the complexity of biological systems and the diversity of cancer development. Fluorescent probes have been extensively utilized for identifying biological substances due to their notable benefits of being non-invasive, quickly responsive, highly sensitive and selective, allowing real-time visualization, and easily modifiable. This review critiques fluorescent probes used for detecting and imaging cancer biomarkers over the last five years. Focuses are made on the design strategies of small-molecule and nano-sized fluorescent probes, the construction methods of fluorescence sensing and imaging platforms, and their further applications in detection of multiple biomarkers, including enzymes, reactive oxygen species, reactive sulfur species, and microenvironments. This review aims to guide the design and development of excellent cancer diagnostic fluorescent probes, and promote the broad application of fluorescence analysis in early cancer diagnosis.

引用

页数：17