A TEMPO promoted tandem reaction of 2-aminobenzophenones and benzylamines under electrochemical conditions

被引：1

作者：

Wang, Yu ^{[1
]}

Huang, Yekai ^{[1
]}

Li, Yanan ^{[1
]}

Li, Kuiliang ^{[1
]}

Luo, Zaigang ^{[1
]}

机构：

[1] Anhui Univ Sci & Technol, Sch Chem & Blasting Engn, Huainan 232001, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 10期

关键词：

OXIDATIVE ANNULATION; HIGHLY POTENT; QUINAZOLINES; INHIBITORS; CYCLIZATION; KETONES; LIGAND;

D O I：

10.1039/d4ob00037d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study describes the efficient synthesis of quinazolines promoted by TEMPO via electro-catalysis with 2-aminobenzophenones and benzylamines. The method exhibited remarkable chemoselectivity under mild reaction conditions. A series of quinazolines could be obtained in moderate to good yields. In addition, control experiments were carried out to verify the reaction mechanism. Furthermore, the synthesis on the gram scale was conducted successfully to give the target product. This study describes the efficient synthesis of quinazolines promoted by TEMPO via electro-catalysis with 2-aminobenzophenones and benzylamines.

引用

页码：1983 / 1987

页数：5

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