Identification and characterization of a novel decalin derivative with anti-Candida activity from Streptomyces chrestomyceticus strain ADP4

被引：1

作者：

Singh, Radha ^{[1
]}

Ali, Mohd. ^{[2
]}

Dubey, Ashok K. ^{[1
]}

机构：

[1] Netaji Subhas Univ Technol, Dept Biol Sci & Engn, New Delhi 110078, India

[2] Hamdard Univ, Fac Pharm, New Delhi 110062, India

来源：

ARCHIVES OF MICROBIOLOGY | 2024年 / 206卷 / 01期

关键词：

Streptomyces; Anti-Candida; C; albicans; auris; Decalin; ADME; Cytotoxicity; CANDIDA-ALBICANS; NATURAL-PRODUCTS; METABOLITES; TOXICITY; BIOFILM; ASSAY;

D O I：

10.1007/s00203-023-03788-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel decalin derivative, trans-1-oxo-2,4-diacetylaminodecalin (1) with anti-Candida activity, had been isolated from Streptomyces chrestomyceticus strain ADP4. The structure of the compound was determined from the analysis of spectral data (LCMS/MS, UV, FTIR, 1D- and 2D-NMR). The anti-Candida activity of 1 was specific to Candida albicans and Candida auris. Further, it displayed inhibition of the early-stage biofilm of C. albicans. In-silico analysis of the compound revealed its drug likeness properties without any violations and PAINS alert when investigated for ADME properties. Along with the overall bioavailability, compound 1 did not show any predicted bioaccumulation and mutagenicity in the analysis by TEST software. Non-cytotoxic property was further confirmed by in-vitro assay on the HepG2 cell line.

引用

页数：9

共 49 条

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