Microwave-assisted synthesis of indolizine derivatives: Recent developments: A review (2003-present)

Microwave-assisted organic synthesis has emerged as the best replacement for the conventional thermal synthetic methodology in organic reactions. It is one of the effective non-conventional activation methods, which has been increasingly used during the past thirty years. Keeping in mind the serious threats to the environment, it is almost mandatory to apply green tools in organic synthesis. A significant decrease in reaction time (from hours to minutes), higher chemical yield and selectivity, and lower chemical waste have made this alternative source of heating an attractive method in chemical transformations. Indolizine is an important heterocyclic scaffold and one of the privileged structural units of heterocycles, and they are found in a wide variety of pharmacophore molecules. The various conjugate derivatives of indolizine also find applications in materials chemistry, in addition to medicinal chemistry. The present mini-review describes microwave-assisted indolizine synthesis, particularly emphasizing recent literature (2003-2023).