Clinicopathologic and genetic features of the starry-sky pattern in double-expressor diffuse large B-cell lymphoma

被引：0

作者：

Sung, Hyun-Jung ^{[1
]}

Kim, Deokhoon ^{[1
]}

Yoon, Dok-Hyun ^{[2
]}

Cho, Hyungwoo ^{[2
]}

Huh, Jooryung ^{[3
]}

Suh, Cheol-Won ^{[3
]}

Go, Heounjeong ^{[1
,4
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul 05505, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul 05505, South Korea

[3] Green Cross Labs, Dept Pathol, Yongin 16924, Gyeonggi, South Korea

[4] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea

来源：

HUMAN PATHOLOGY | 2023年 / 139卷

关键词：

Double expressor lym-phoma; Starry-sky pattern; Diffuse large B-cell lymphoma; c-MYC; Prognosis; KMT2D; INFERIOR SURVIVAL; PROGNOSTIC-FACTOR; BURKITT-LYMPHOMA; MYC; IMMUNOHISTOCHEMISTRY; CLASSIFICATION; OVEREXPRESSION; SIGNATURES; SUBTYPES; RISK;

D O I：

10.1016/j.humpath.2023.07.008

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Double expressor lymphoma (DEL) is a subset of diffuse large B-cell lymphoma (DLBCL) characterized by the co-expression of MYC and BCL2 proteins with a poor prognosis. However, there are no standard criteria for evaluating the morphologic features of DEL. We aimed to analyze the prognostic value of the starry-sky pattern (SSP) and its correlation with clinicopathologic and genetic features in 153 DEL cases. The SSP was significantly associated with aggressive parameters, including c-MYC overexpression, CD5 expression, higher IPI, and age-adjusted IPI. In the univariate survival analyses, the presence of SSP was associated with unfavorable progression-free survival (PFS) (p = 0.040), and tended towards an adverse overall survival (OS) (p = 0.061). However, when c-MYC was overexpressed, SSP was significantly correlated with inferior OS (p = 0.019). In the multi-variate survival analysis, SSP was also associated with poor PFS (p = 0.048). Additionally, next -generation sequencing data revealed SSP was significantly associated with the KMT2D mutation and had different genetic mutation profiles from non-SSP. In conclusion, SSP may represent morpho-logic characteristics of aggressiveness in DEL. & COPY; 2023 Elsevier Inc. All rights reserved.

引用

页码：106 / 116

页数：11

共 38 条

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