Clinicopathologic and genetic features of the starry-sky pattern in double-expressor diffuse large B-cell lymphoma

被引:0
作者
Sung, Hyun-Jung [1 ]
Kim, Deokhoon [1 ]
Yoon, Dok-Hyun [2 ]
Cho, Hyungwoo [2 ]
Huh, Jooryung [3 ]
Suh, Cheol-Won [3 ]
Go, Heounjeong [1 ,4 ]
机构
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul 05505, South Korea
[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul 05505, South Korea
[3] Green Cross Labs, Dept Pathol, Yongin 16924, Gyeonggi, South Korea
[4] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea
关键词
Double expressor lym-phoma; Starry-sky pattern; Diffuse large B-cell lymphoma; c-MYC; Prognosis; KMT2D; INFERIOR SURVIVAL; PROGNOSTIC-FACTOR; BURKITT-LYMPHOMA; MYC; IMMUNOHISTOCHEMISTRY; CLASSIFICATION; OVEREXPRESSION; SIGNATURES; SUBTYPES; RISK;
D O I
10.1016/j.humpath.2023.07.008
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Double expressor lymphoma (DEL) is a subset of diffuse large B-cell lymphoma (DLBCL) characterized by the co-expression of MYC and BCL2 proteins with a poor prognosis. However, there are no standard criteria for evaluating the morphologic features of DEL. We aimed to analyze the prognostic value of the starry-sky pattern (SSP) and its correlation with clinicopathologic and genetic features in 153 DEL cases. The SSP was significantly associated with aggressive parameters, including c-MYC overexpression, CD5 expression, higher IPI, and age-adjusted IPI. In the univariate survival analyses, the presence of SSP was associated with unfavorable progression-free survival (PFS) (p = 0.040), and tended towards an adverse overall survival (OS) (p = 0.061). However, when c-MYC was overexpressed, SSP was significantly correlated with inferior OS (p = 0.019). In the multi-variate survival analysis, SSP was also associated with poor PFS (p = 0.048). Additionally, next -generation sequencing data revealed SSP was significantly associated with the KMT2D mutation and had different genetic mutation profiles from non-SSP. In conclusion, SSP may represent morpho-logic characteristics of aggressiveness in DEL. & COPY; 2023 Elsevier Inc. All rights reserved.
引用
收藏
页码:106 / 116
页数:11
相关论文
共 38 条
[11]   Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review [J].
Fedchenko, Nickolay ;
Reifenrath, Janin .
DIAGNOSTIC PATHOLOGY, 2014, 9 :221
[12]   Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray [J].
Hans, CP ;
Weisenburger, DD ;
Greiner, TC ;
Gascoyne, RD ;
Delabie, J ;
Ott, G ;
Müller-Hermelink, HK ;
Campo, E ;
Braziel, RM ;
Jaffe, ES ;
Pan, ZG ;
Farinha, P ;
Smith, LM ;
Falini, B ;
Banham, AH ;
Rosenwald, A ;
Staudt, LM ;
Connors, JM ;
Armitage, JO ;
Chan, WC .
BLOOD, 2004, 103 (01) :275-282
[13]   Double-Expressor Phenotype (BCL-2/c-MYC Co-expression) of Diffuse Large B-Cell Lymphoma and Its Clinicopathological Correlation [J].
Hashmi, Atif A. ;
Iftikhar, Syeda N. ;
Nargus, Gul ;
Ahmed, Omer ;
Asghar, Ishaq Azeem ;
Shirazi, Umme Aiman ;
Afzal, Anoshia ;
Irfan, Muhammad ;
Ali, Javaria .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (02)
[14]   MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program [J].
Hu, Shimin ;
Xu-Monette, Zijun Y. ;
Tzankov, Alexander ;
Green, Tina ;
Wu, Lin ;
Balasubramanyam, Aarthi ;
Liu, Wei-min ;
Visco, Carlo ;
Li, Yong ;
Miranda, Roberto N. ;
Montes-Moreno, Santiago ;
Dybkaer, Karen ;
Chiu, April ;
Orazi, Attilio ;
Zu, Youli ;
Bhagat, Govind ;
Richards, Kristy L. ;
Hsi, Eric D. ;
Choi, William W. L. ;
Zhao, Xiaoying ;
van Krieken, J. Han ;
Huang, Qin ;
Huh, Jooryung ;
Ai, Weiyun ;
Ponzoni, Maurilio ;
Ferreri, Andres J. M. ;
Zhou, Fan ;
Slack, Graham W. ;
Gascoyne, Randy D. ;
Tu, Meifeng ;
Variakojis, Daina ;
Chen, Weina ;
Go, Ronald S. ;
Piris, Miguel A. ;
Moller, Michael B. ;
Medeiros, L. Jeffrey ;
Young, Ken H. .
BLOOD, 2013, 121 (20) :4021-4031
[15]   The Incidence and Treatment Response of Double Expression of MYC and BCL2 in Patients with Diffuse Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis [J].
Hwang, Jisun ;
Suh, Chonghyun ;
Kim, Kyungwon ;
Kim, Hosung ;
Kim, Austin I. ;
Craig, Jeffrey W. ;
Chen, Ke Xun ;
Roberson, Joel ;
Guenette, Jeffrey P. ;
Huang, Raymond Y. .
CANCERS, 2021, 13 (13)
[16]   Diffuse large B-cell lymphomas with CDKN2A deletion have a distinct gene expression signature and a poor prognosis under R-CHOP treatment: a GELA study [J].
Jardin, Fabrice ;
Jais, Jean-Philippe ;
Molina, Thierry-Jo ;
Parmentier, Francoise ;
Picquenot, Jean-Michel ;
Ruminy, Philippe ;
Tilly, Herve ;
Bastard, Christian ;
Salles, Gilles-Andre ;
Feugier, Pierre ;
Thieblemont, Catherine ;
Gisselbrecht, Christian ;
de Reynies, Aurelien ;
Coiffier, Bertrand ;
Haioun, Corinne ;
Leroy, Karen .
BLOOD, 2010, 116 (07) :1092-1104
[17]   Concurrent Expression of MYC and BCL2 in Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone [J].
Johnson, Nathalie A. ;
Slack, Graham W. ;
Savage, Kerry J. ;
Connors, Joseph M. ;
Ben-Neriah, Susana ;
Rogic, Sanja ;
Scott, David W. ;
Tan, King L. ;
Steidl, Christian ;
Sehn, Laurie H. ;
Chan, Wing C. ;
Iqbal, Javeed ;
Meyer, Paul N. ;
Lenz, Georg ;
Wright, George ;
Rimsza, Lisa M. ;
Valentino, Carlo ;
Brunhoeber, Patrick ;
Grogan, Thomas M. ;
Braziel, Rita M. ;
Cook, James R. ;
Tubbs, Raymond R. ;
Weisenburger, Dennis D. ;
Campo, Elias ;
Rosenwald, Andreas ;
Ott, German ;
Delabie, Jan ;
Holcroft, Christina ;
Jaffe, Elaine S. ;
Staudt, Louis M. ;
Gascoyne, Randy D. .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (28) :3452-3459
[18]   Outcomes of patients with relapsed/refractory double-expressor B-cell lymphoma treated with ibrutinib monotherapy [J].
Landsburg, Daniel J. ;
Hughes, Mitchell E. ;
Koike, Alexa ;
Bond, David ;
Maddocks, Kami J. ;
Guo, Ling ;
Winter, Allison M. ;
Hill, Brian T. ;
Ondrejka, Sarah L. ;
Hsi, Eric D. ;
Nasta, Sunita D. ;
Svoboda, Jakub ;
Schuster, Stephen J. ;
Bogusz, Agata M. .
BLOOD ADVANCES, 2019, 3 (02) :132-135
[19]   Stromal Gene Signatures in Large-B-Cell Lymphomas [J].
Lenz, G. ;
Wright, G. ;
Dave, S. S. ;
Xiao, W. ;
Powell, J. ;
Zhao, H. ;
Xu, W. ;
Tan, B. ;
Goldschmidt, N. ;
Iqbal, J. ;
Vose, J. ;
Bast, M. ;
Fu, K. ;
Weisenburger, D. D. ;
Greiner, T. C. ;
Armitage, J. O. ;
Kyle, A. ;
May, L. ;
Gascoyne, R. D. ;
Connors, J. M. ;
Troen, G. ;
Holte, H. ;
Kvaloy, S. ;
Dierickx, D. ;
Verhoef, G. ;
Delabie, J. ;
Smeland, E. B. ;
Jares, P. ;
Martinez, A. ;
Lopez-Guillermo, A. ;
Montserrat, E. ;
Campo, E. ;
Braziel, R. M. ;
Miller, T. P. ;
Rimsza, L. M. ;
Cook, J. R. ;
Pohlman, B. ;
Sweetenham, J. ;
Tubbs, R. R. ;
Fisher, R. I. ;
Hartmann, E. ;
Rosenwald, A. ;
Ott, G. ;
Muller-Hermelink, H. -K ;
Wrench, D. ;
Lister, T. A. ;
Jaffe, E. S. ;
Wilson, W. H. ;
Chan, W. C. ;
Staudt, L. M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (22) :2313-2323
[20]   Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways [J].
Lenz, Georg ;
Wright, George W. ;
Emre, N. C. Tolga ;
Kohlhammer, Holger ;
Dave, Sandeep S. ;
Davis, R. Eric ;
Carty, Shannon ;
Lam, Lloyd T. ;
Shaffer, A. L. ;
Xiao, Wenming ;
Powell, John ;
Rosenwald, Andreas ;
Ott, German ;
Muller-Hermelink, Hans Konrad ;
Gascoyne, Randy D. ;
Connors, Joseph M. ;
Campo, Elias ;
Jaffe, Elaine S. ;
Delabie, Jan ;
Smeland, Erlend B. ;
Rimsza, Lisa M. ;
Fisher, Richard I. ;
Weisenburger, Dennis D. ;
Chan, Wing C. ;
Staudt, Louis M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (36) :13520-13525