Mutational landscape and predictors of survival in head and neck mucosal melanoma

被引：2
作者：
Lehrich, Brandon M. [1 ,2 ]
Abiri, Arash [3 ,4 ]
Nguyen, Theodore V. [4 ]
Bitner, Benjamin F. [4 ]
Tong, Charles C. L. [5 ]
Kuan, Edward C. [4 ,6 ,7 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA
[2] Univ Pittsburgh, Med Sci Training Program, Pittsburgh, PA USA
[3] Univ Calif Irvine, Med Sci Training Program, Irvine, CA USA
[4] Univ Calif Irvine, Dept Otolaryngol, Irvine, CA USA
[5] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Otolaryngol, New York, NY USA
[6] Univ Calif Irvine, Dept Neurol Surg, Irvine, CA USA
[7] Univ Calif Irvine, 101 City Dr, South Orange, CA 92868 USA
来源：
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY | 2024年 / 14卷 / 04期
基金：
美国国家卫生研究院;
关键词：
mucosal melanoma; patient survival; tumor genetics; tumor mutational burden;
D O I：
10.1002/alr.23267
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Key PointsHead and neck mucosal melanomas have a diverse mutational landscape with low mutational burden.A molecular subset (& SIM;13%) has ROS1 mutations, which is an actionable driver mutation.ROS1-mutated patients have improved overall survival likely due to high mutational burden.
引用
收藏
页码：858 / 861
页数：4
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  • [1] Adjuvant Therapy and Prognosticators of Survival in Head and Neck Mucosal Melanoma
    Abiri, Arash
    Yasaka, Tyler M.
    Lehrich, Brandon M.
    Goshtasbi, Khodayar
    Papagiannopoulos, Peter
    Tajudeen, Bobby A.
    St. John, Maie A.
    Harris, Jeremy P.
    Kuan, Edward C.
    [J]. LARYNGOSCOPE, 2022, 132 (03) : 584 - 592
  • [2] AACR Project GENIE: Powering Precision Medicine through an International Consortium
    Andre, Fabrice
    Arnedos, Monica
    Baras, Alexander S.
    Baselga, Jose
    Bedard, Philippe L.
    Berger, Michael F.
    Bierkens, Mariska
    Calvo, Fabien
    Cerami, Ethan
    Chakravarty, Debyani
    Dang, Kristen K.
    Davidson, Nancy E.
    Del Vecchio, Fitz Catherine
    Dogan, Semih
    DuBois, Raymond N.
    Ducar, Matthew D.
    Futreal, P. Andrew
    Gao Jianjiong
    Garcia, Francisco
    Gardos, Stu
    Gocke, Christopher D.
    Gross, Benjamin E.
    Guinney, Justin
    Heins, Zachary J.
    Hintzen, Stephanie
    Horlings, Hugo
    Hudecek, Jan
    Hyman, David M.
    Kamel-Reid, Suzanne
    Kandoth, Cyriac
    Kinyua, Walter
    Kumari, Priti
    Kundra, Ritika
    Ladanyi, Marc
    Lefebvre, Celine
    LeNoue-Newton, Michele L.
    Lepisto, Eva M.
    Levy, Mia A.
    Lindeman, Neal, I
    Lindsay, James
    Liu, David
    Lu Zhibin
    MacConaill, Laura E.
    Ian, Maurer
    Maxwell, David S.
    Meijer, Gerrit A.
    Meric-Bernstam, Funda
    Micheel, Christine M.
    Miller, Clinton
    Mills, Gordon
    [J]. CANCER DISCOVERY, 2017, 7 (08) : 818 - 831
  • [3] Case report: complete remission with crizotinib in ROS1 fusion-positive sinonasal mucosal melanoma
    Cao, Jun
    Yu, Yaner
    Zhou, Yangkun
    Ji, Qing
    Qian, Wenkang
    Jia, Dongdong
    Jin, Gu
    Qi, Yajun
    Li, Xin
    Li, Ningning
    Li, Tao
    Fang, Meiyu
    Jin, Hongchuan
    [J]. FRONTIERS IN ONCOLOGY, 2022, 12
  • [4] Sinonasal Mucosal Melanoma: Role of Tumor Proliferative Indices and Pathological Factors in Survival
    Guo, Ruifeng
    Jenkins, Sarah M.
    Johnson, Brian J.
    Reed, Katelyn
    Kroneman, Trynda
    Choby, Garret
    [J]. LARYNGOSCOPE, 2022, 132 (12) : 2350 - 2358
  • [5] Mucosal Melanoma of the Head and Neck: A Systematic Review of the Literature
    Lazarev, Stanislav
    Gupta, Vishal
    Hu, Kenneth
    Harrison, Louis B.
    Bakst, Richard
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2014, 90 (05): : 1108 - 1118
  • [6] International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System
    Lechner, Matt
    Takahashi, Yoko
    Turri-Zanoni, Mario
    Ferrari, Marco
    Liu, Jacklyn
    Counsell, Nicholas
    Mattavelli, Davide
    Rampinelli, Vittorio
    Vermi, William
    Lombardi, Davide
    Saade, Rami
    Park, Ki Wan
    Schartinger, Volker H.
    Franchi, Alessandro
    Facco, Carla
    Sessa, Fausto
    Battocchio, Simonetta
    Fenton, Tim R.
    Vaz, Francis M.
    O'Flynn, Paul
    Howard, David
    Stimpson, Paul
    Wang, Simon
    Hannan, S. Alam
    Unadkat, Samit
    Hughes, Jonathan
    Dwivedi, Raghav
    Forde, Cillian T.
    Randhawa, Premjit
    Gane, Simon
    Joseph, Jonathan
    Andrews, Peter J.
    Dave, Manas
    Fleming, Jason C.
    Thomson, David
    Zhu, Tianyu
    Teschendorff, Andrew
    Royle, Gary
    Steele, Christopher
    Jimenez, Joaquin E.
    Laco, Jan
    Wang, Eric W.
    Snyderman, Carl
    Lacy, Peter D.
    Woods, Robbie
    O'Neill, James P.
    Saraswathula, Anirudh
    Kaur, Raman Preet
    Zhao, Tianna
    Ramanathan, Murugappan, Jr.
    [J]. JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 2023, 84 (04) : 307 - 319
  • [7] Update on primary head and neck mucosal melanoma
    Lopez, Fernando
    Rodrigo, Juan P.
    Cardesa, Antonio
    Triantafyllou, Asterios
    Devaney, Kenneth O.
    Mendenhall, William M.
    Haigentz, Missak, Jr.
    Strojan, Primoz
    Pellitteri, Phillip K.
    Bradford, Carol R.
    Shaha, Ashok R.
    Hunt, Jennifer L.
    de Bree, Remco
    Takes, Robert P.
    Rinaldo, Alessandra
    Ferlito, Alfio
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2016, 38 (01): : 147 - 155
  • [8] De Novo Mutation in Non-Tyrosine Kinase Domain of ROS1 ads a Potential Predictor of Immune Checkpoint Inhibitors in Melanoma
    Ma, Si-Cong
    Zhu, Hong-Bo
    Wang, Jian
    Zhang, Yan-Pei
    Guo, Xue-Jun
    Long, Li-Li
    Guo, Ze-Qin
    Wu, De-Hua
    Dong, Zhong-Yi
    Bai, Xue
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
  • [9] Crizotinib in ROS1-rearranged advanced non-small-cell lung cancer (NSCLC): updated results, including overall survival, from PROFILE 1001
    Shaw, A. T.
    Riely, G. J.
    Bang, Y-J
    Kim, D-W
    Camidge, D. R.
    Solomon, B. J.
    Varella-Garcia, M.
    Iafrate, A. J.
    Shapiro, G., I
    Usari, T.
    Wang, S. C.
    Wilner, K. D.
    Clark, J. W.
    Ou, S-H, I
    [J]. ANNALS OF ONCOLOGY, 2019, 30 (07) : 1121 - 1126
  • [10] Analysis of Mucosal Melanoma Whole-Genome Landscapes Reveals Clinically Relevant Genomic Aberrations
    Zhou, Rong
    Shi, Chaoji
    Tao, Wenjie
    Li, Jiang
    Wu, Jing
    Han, Yong
    Yang, Guizhu
    Gu, Ziyue
    Xu, Shengming
    Wang, Yujue
    Wang, Lizhen
    Wang, Yanan
    Zhou, Guoyu
    Zhang, Chenping
    Zhang, Zhiyuan
    Sun, Shuyang
    [J]. CLINICAL CANCER RESEARCH, 2019, 25 (12) : 3548 - 3560
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