Progress in genome-wide association studies of age at natural menopause

被引：7

作者：

Xu, Che ^{[1
]}

Ruan, Xiangyan ^{[1
,2
,3
]}

Mueck, Alfred O. ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Dept Gynecol Endocrinol, Beijing, Peoples R China

[2] Univ Tubingen, Univ Womens Hosp, Tubingen, Germany

[3] Univ Tubingen, Res Ctr Womens Hlth, Dept Womens Hlth, Tubingen, Germany

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2023年 / 46卷 / 03期

基金：

北京市自然科学基金;

关键词：

Age at natural menopause; DNA damage repair; Epidemiology; Genome-wide association study; Menopause; Trans-ethnic; PRIMARY OVARIAN INSUFFICIENCY; ESTROGEN-RECEPTOR-ALPHA; MENARCHE; LOCI; GENE; POLYMORPHISMS; VARIANTS; REPAIR; WOMEN; ONSET;

D O I：

10.1016/j.rbmo.2022.11.017

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Menopause is not only the end of reproductive life, it is also related to diseases such as hyperlipidaemia, atherosclerotic cardiovascular disease, osteoporosis and breast cancer. Traditional epidemiological studies have found that heredity is the main determinant of age at natural menopause (ANM). Early studies on genetic factors were limited to candidate gene studies. Menopause age is not inherited by a single gene, but is the result of multiple gene effects. With the development of genomic technology, the Reproductive Genetics Consortium conducted several genome-wide association studies on ANM in people of European descent, and found that defects in DNA damage repair pathways were the main genetic mechanism. In recent years, due to the ethnic heterogeneity of ANM, there has been further development of global studies into multi-ethnic and trans-ethnic genome-wide association studies. Further genetic and epidemiological studies, including polygenetic score and genetic mechanism research, should be conducted to investigate the pathogenesis and mechanism with respect to menopause and its related diseases.

引用

页码：607 / 622

页数：16

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