Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice

被引:21
作者
Wali, Jibran A. [1 ,2 ]
Ni, Duan [1 ,3 ]
Facey, Harrison J. W. [1 ]
Dodgson, Tim [1 ,2 ]
Pulpitel, Tamara J. [1 ,2 ]
Senior, Alistair M. [1 ,2 ,4 ]
Raubenheimer, David [1 ,2 ]
Macia, Laurence [1 ,3 ,5 ]
Simpson, Stephen J. [1 ,2 ]
机构
[1] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia
[2] Univ Sydney, Sch Life & Environm Sci, Fac Sci, Sydney, NSW, Australia
[3] Univ Sydney, Sch Med Sci, Fac Med & Hlth, Chron Dis Theme, Sydney, NSW, Australia
[4] Univ Sydney, Sydney Precis Data Sci Ctr, Sydney, NSW, Australia
[5] Univ Sydney, Sydney Cytometry, Sydney, NSW, Australia
基金
英国医学研究理事会;
关键词
SWEETENED BEVERAGES; FRUCTOSE; INSULIN; GLUCOSE; LIPOGENESIS;
D O I
10.1038/s41467-023-40039-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The metabolic effects of sugars and fat lie at the heart of the "carbohydrate vs fat" debate on the global obesity epidemic. Here, we use nutritional geometry to systematically investigate the interaction between dietary fat and the major monosaccharides, fructose and glucose, and their impact on body composition and metabolic health. Male mice (n=245) are maintained on one of 18 isocaloric diets for 18-19 weeks and their metabolic status is assessed through in vivo procedures and by in vitro assays involving harvested tissue samples. We find that in the setting of low and medium dietary fat content, a 50:50 mixture of fructose and glucose (similar to high-fructose corn syrup) is more obesogenic and metabolically adverse than when either monosaccharide is consumed alone. With increasing dietary fat content, the effects of dietary sugar composition on metabolic status become less pronounced. Moreover, higher fat intake is more harmful for glucose tolerance and insulin sensitivity irrespective of the sugar mix consumed. The type of fat consumed (soy oil vs lard) does not modify these outcomes. Our work shows that both dietary fat and sugars can lead to adverse metabolic outcomes, depending on the dietary context. This study shows how the principles of the two seemingly conflicting models of obesity (the "energy balance model" and the "carbohydrate insulin model") can be valid, and it will help in progressing towards a unified model of obesity. The main limitations of this study include the use of male mice of a single strain, and not testing the metabolic effects of fructose intake via sugary drinks, which are strongly linked to human obesity.
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页数:12
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共 53 条
  • [1] Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men
    Akhavan, Tina
    Anderson, G. Harvey
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 86 (05) : 1354 - 1363
  • [2] THE USE OF AREAS UNDER CURVES IN DIABETES RESEARCH
    ALLISON, DB
    PAULTRE, F
    MAGGIO, C
    MEZZITIS, N
    PISUNYER, FX
    [J]. DIABETES CARE, 1995, 18 (02) : 245 - 250
  • [3] Maternal fructose drives placental uric acid production leading to adverse fetal outcomes
    Asghar, Zeenat A.
    Thompson, Alysha
    Chi, Maggie
    Cusumano, Andrew
    Scheaffer, Suzanne
    Al-Hammadi, Noor
    Saben, Jessica L.
    Moley, Kelle H.
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [4] The role of low-fat diets in body weight control:: a meta-analysis of ad libitum dietary intervention studies
    Astrup, A
    Grunwald, GK
    Melanson, EL
    Saris, WHM
    Hill, JO
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (12) : 1545 - 1552
  • [5] Bray GA, 2004, AM J CLIN NUTR, V79, P537
  • [6] Saccharide Characteristics and Their Potential Health Effects in Perspective
    Brouns, Fred
    [J]. FRONTIERS IN NUTRITION, 2020, 7
  • [7] Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials
    Bueno, Nassib Bezerra
    Vieira de Melo, Ingrid Sofia
    de Oliveira, Suzana Lima
    Ataide, Terezinha da Rocha
    [J]. BRITISH JOURNAL OF NUTRITION, 2013, 110 (07) : 1178 - 1187
  • [8] A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice
    Duarte, Joao A. G.
    Carvalho, Filipa
    Pearson, Mackenzie
    Horton, Jay D.
    Browning, Jeffrey D.
    Jones, John G.
    Burgess, Shawn C.
    [J]. JOURNAL OF LIPID RESEARCH, 2014, 55 (12) : 2541 - 2553
  • [9] Physiological aspects of energy metabolism and gastrointestinal effects of carbohydrates
    Elia, M.
    Cummings, J. H.
    [J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2007, 61 : S40 - S74
  • [10] Assessment of Feeding Behavior in Laboratory Mice
    Ellacott, Kate L. J.
    Morton, Gregory J.
    Woods, Stephen C.
    Tso, Patrick
    Schwartz, Michael W.
    [J]. CELL METABOLISM, 2010, 12 (01) : 10 - 17