Mitochondria during T cell aging

被引：13

作者：

Escrig-Larena, Jose Ignacio ^{[1
]}

Delgado-Pulido, Sandra ^{[2
]}

Mittelbrunn, Maria ^{[1
]}

机构：

[1] Univ Autonoma Madrid UAM, Ctr Biol Molcular Severo Ochoa CSIC UAM, CSIC, Madrid, Spain

[2] Univ Autonoma Madrid UAM, Fac Ciencias UAM, Ctr Biol Mol Severo Ochoa CS UAM, Dept Biol Mol, Madrid, Spain

来源：

SEMINARS IN IMMUNOLOGY | 2023年 / 69卷

关键词：

Mitochondria; Lymphocyte; Inflammaging; T cells; Aging; MtDNA; Mitokines; Mitochondrial dynamics; ROS; Calcium homeostasis; Apoptosis; Mitophagy; INTEGRATED STRESS-RESPONSE; AGE-ASSOCIATED CHANGES; OXIDATIVE STRESS; METABOLIC CHECKPOINT; TRANSCRIPTION FACTOR; LIFE-SPAN; ACTIVATION; APOPTOSIS; DYSFUNCTION; MEMORY;

D O I：

10.1016/j.smim.2023.101808

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is characterized by al-terations of the mitochondrial DNA, reduced respiratory capacity, decreased mitochondrial membrane potential and increased reactive oxygen species production. These primary alterations disrupt other interconnected and important mitochondrial-related processes such as metabolism, mitochondrial dynamics and biogenesis, mitophagy, calcium homeostasis or apoptosis. In this review, we gather the current knowledge about the different mitochondrial processes which are altered during aging, with special focus on their contribution to age-associated T cell dysfunction and inflammaging.

引用

页数：13

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