The Gastrointestinal Tract Is Pinpointed as a Reservoir of Candida albicans, Candida parapsilosis, and Candida tropicalis Genotypes Found in Blood and Intra-Abdominal Samples

被引:3
|
作者
Mesquida, Aina [1 ,2 ]
Machado, Marina [1 ,2 ]
Davila-Cherres, Lorena [1 ,2 ]
Vicente, Teresa [1 ,2 ]
Sanchez-Carrillo, Carlos [1 ,2 ,3 ]
Alcala, Luis [1 ,2 ,3 ]
Reigadas, Elena [1 ,2 ,3 ,4 ]
Munoz, Patricia [1 ,2 ,3 ,4 ]
Guinea, Jesus [1 ,2 ,3 ]
Escribano, Pilar [1 ,2 ,5 ]
机构
[1] Hosp Gen Univ Gregorio Maranon, Clin Microbiol & Infect Dis Dept, C Dr Esquerdo 46, Madrid 28007, Spain
[2] Inst Invest Sanitaria Gregorio Maranon, Madrid 28007, Spain
[3] CIBER Enfermedades Resp CIBERES CB06 06 0058, Madrid 28029, Spain
[4] Univ Complutense Madrid, Sch Med, Dept Med, Madrid 28040, Spain
[5] Camilo Jose Cela Univ, HM Hosp, Sch Hlth Sci, Madrid 28692, Spain
关键词
genotyping; Candida; candidaemia; gastro-intestinal tract; INVASIVE CANDIDIASIS; COLONIZATION; FUNGEMIA; FUNGI;
D O I
10.3390/jof9070732
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Background: Candida spp., as part of the microbiota, can colonise the gastrointestinal tract. We hypothesised that genotyping Candida spp. isolates from the gastrointestinal tract could help spot genotypes able to cause invasive infections. Materials/methods: A total of 816 isolates of C. albicans (n = 595), C. parapsilosis (n = 118), and C. tropicalis (n = 103) from rectal swabs (n = 754 patients) were studied. Genotyping was conducted using species-specific microsatellite markers. Rectal swab genotypes were compared with previously studied blood (n = 814) and intra-abdominal (n = 202) genotypes. Results: A total of 36/754 patients had the same Candida spp. isolated from blood cultures, intra-abdominal samples, or both; these patients had candidemia (n = 18), intra-abdominal candidiasis (n = 11), both clinical forms (n = 1), and non-significant isolation (n = 6). Genotypes matching the rectal swab and their blood cultures (84.2%) or their intra-abdominal samples (92.3%) were found in most of the significant patients. We detected 656 genotypes from rectal swabs, 88.4% of which were singletons and 11.6% were clusters. Of these 656 rectal swab genotypes, 94 (14.3%) were also detected in blood cultures and 34 (5.2%) in intra-abdominal samples. Of the rectal swab clusters, 62.7% were previously defined as a widespread genotype. Conclusions: Our study pinpoints the gastrointestinal tract as a potential reservoir of potentially invasive Candida spp. genotypes.
引用
收藏
页数:11
相关论文
共 50 条
  • [41] MORPHOLOGICAL ASPECTS OF GASTROINTESTINAL-TRACT INVASION BY CANDIDA-ALBICANS IN THE INFANT MOUSE
    COLE, GT
    SESHAN, KR
    POPE, LM
    YANCEY, RJ
    JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY, 1988, 26 (03): : 173 - 185
  • [42] Impact of changes at the Candida albicans cell surface upon immunogenicity and colonisation in the gastrointestinal tract
    Avelar, Gabriela M.
    Dambuza, Ivy M.
    Ricci, Liviana
    Yuecel, Raif
    Mackenzie, Kevin
    Childers, Delma S.
    Bain, Judith M.
    Pradhan, Arnab
    Larcombe, Daniel E.
    Netea, Mihai G.
    Erwig, Lars P.
    Brown, Gordon D.
    Duncan, Sylvia H.
    Gow, Neil A. R.
    Walker, Alan W.
    Brown, Alistair J. P.
    CELL SURFACE, 2022, 8
  • [43] A piglet model for studying Candida albicans colonization of the human oro-gastrointestinal tract
    Hoeflinger, Jennifer L.
    Coleman, David A.
    Oh, Soon-Hwan
    Miller, Michael J.
    Hoyer, Lois L.
    FEMS MICROBIOLOGY LETTERS, 2014, 357 (01) : 10 - 15
  • [44] Microbiota signatures associated with invasive Candida albicans infection in the gastrointestinal tract of immunodeficient mice
    Yan, Jia-Ying
    Lin, Tsung-Han
    Jong, Yu-Tang
    Hsueh, Jun-Wei
    Wu, Sze-Hsien
    Lo, Hsiu-Jung
    Chen, Yee-Chun
    Pan, Chien-Hsiung
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2024, 13
  • [45] FACTORS INVOLVED IN CANDIDA-ALBICANS COLONIZATION OF GASTROINTESTINAL-TRACT OF WHITE MOUSE
    AUGER, P
    JOLY, J
    CANADIAN JOURNAL OF MICROBIOLOGY, 1976, 22 (03) : 334 - 337
  • [46] A fungal metabolic regulator underlies infectious synergism during Candida albicans-Staphylococcusaureus intra-abdominal co-infection
    Paul, Saikat
    Todd, Olivia A.
    Eichelberger, Kara R.
    Tkaczyk, Christine
    Sellman, Bret R.
    Noverr, Mairi C.
    Cassat, James E.
    Fidel Jr, Paul L.
    Peters, Brian M.
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [47] Treatment of intra-abdominal abscesses caused by Candida albicans with antifungal agents and recombinant murine granulocyte colony-stimulating factor
    Vonk, AG
    Netea, MG
    van Krieken, JH
    Verweij, PE
    van der Meer, JWM
    Kullberg, BJ
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (12) : 3688 - 3693
  • [48] Holotoxin A1 from Apostichopus japonicus inhibited oropharyngeal and intra-abdominal candidiasis by inducing oxidative damage in Candida albicans
    Liao, Min
    Xia, Xuekui
    Meng, Qingzhou
    Zhu, Chengguang
    Liao, Binyou
    Wang, Jiannan
    Gou, Lichen
    Zhou, Xuedong
    Yuan, Wenpeng
    Cheng, Lei
    Ren, Biao
    BRITISH JOURNAL OF PHARMACOLOGY, 2024, 181 (12) : 1857 - 1873
  • [49] Candida glabrata Intra-Abdominal Candidiasis Is Characterized by Persistence within the Peritoneal Cavity and Abscesses
    Cheng, Shaoji
    Clancy, Cornelius J.
    Hartman, Douglas J.
    Hao, Binghua
    Nguyen, M. Hong
    INFECTION AND IMMUNITY, 2014, 82 (07) : 3015 - 3022
  • [50] Non-Candida isolates from blood cultures and intra-abdominal samples: data derived from a multicentre prospective study conducted in Madrid
    Diaz-Garcia, Judith
    Gomez, Ana
    Machado, Marina
    Alcala, Luis
    Reigadas, Elena
    Sanchez-Carrillo, Carlos
    Perez-Ayala, Ana
    Gomez-Garcia de la Pedrosa, Elia
    Gonzalez-Romo, Fernando
    Soledad Cuetara, Maria
    Garcia-Esteban, Coral
    Quiles-Melero, Inmaculada
    Daniela Zurita, Nelly
    Munoz-Algarra, Maria
    Duran-Valle, Maria Teresa
    Sanchez-Garcia, Aida
    Munoz, Patricia
    Escribano, Pilar
    Guinea, Jesus
    REVISTA ESPANOLA DE QUIMIOTERAPIA, 2023, 36 (05) : 541 - 544