The Gastrointestinal Tract Is Pinpointed as a Reservoir of Candida albicans, Candida parapsilosis, and Candida tropicalis Genotypes Found in Blood and Intra-Abdominal Samples

被引:3
|
作者
Mesquida, Aina [1 ,2 ]
Machado, Marina [1 ,2 ]
Davila-Cherres, Lorena [1 ,2 ]
Vicente, Teresa [1 ,2 ]
Sanchez-Carrillo, Carlos [1 ,2 ,3 ]
Alcala, Luis [1 ,2 ,3 ]
Reigadas, Elena [1 ,2 ,3 ,4 ]
Munoz, Patricia [1 ,2 ,3 ,4 ]
Guinea, Jesus [1 ,2 ,3 ]
Escribano, Pilar [1 ,2 ,5 ]
机构
[1] Hosp Gen Univ Gregorio Maranon, Clin Microbiol & Infect Dis Dept, C Dr Esquerdo 46, Madrid 28007, Spain
[2] Inst Invest Sanitaria Gregorio Maranon, Madrid 28007, Spain
[3] CIBER Enfermedades Resp CIBERES CB06 06 0058, Madrid 28029, Spain
[4] Univ Complutense Madrid, Sch Med, Dept Med, Madrid 28040, Spain
[5] Camilo Jose Cela Univ, HM Hosp, Sch Hlth Sci, Madrid 28692, Spain
关键词
genotyping; Candida; candidaemia; gastro-intestinal tract; INVASIVE CANDIDIASIS; COLONIZATION; FUNGEMIA; FUNGI;
D O I
10.3390/jof9070732
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Background: Candida spp., as part of the microbiota, can colonise the gastrointestinal tract. We hypothesised that genotyping Candida spp. isolates from the gastrointestinal tract could help spot genotypes able to cause invasive infections. Materials/methods: A total of 816 isolates of C. albicans (n = 595), C. parapsilosis (n = 118), and C. tropicalis (n = 103) from rectal swabs (n = 754 patients) were studied. Genotyping was conducted using species-specific microsatellite markers. Rectal swab genotypes were compared with previously studied blood (n = 814) and intra-abdominal (n = 202) genotypes. Results: A total of 36/754 patients had the same Candida spp. isolated from blood cultures, intra-abdominal samples, or both; these patients had candidemia (n = 18), intra-abdominal candidiasis (n = 11), both clinical forms (n = 1), and non-significant isolation (n = 6). Genotypes matching the rectal swab and their blood cultures (84.2%) or their intra-abdominal samples (92.3%) were found in most of the significant patients. We detected 656 genotypes from rectal swabs, 88.4% of which were singletons and 11.6% were clusters. Of these 656 rectal swab genotypes, 94 (14.3%) were also detected in blood cultures and 34 (5.2%) in intra-abdominal samples. Of the rectal swab clusters, 62.7% were previously defined as a widespread genotype. Conclusions: Our study pinpoints the gastrointestinal tract as a potential reservoir of potentially invasive Candida spp. genotypes.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Sustained gastrointestinal colonization and systemic dissemination by Candida albicans, Candida tropicalis and Candida parapsilosis in adult mice
    Mellado, E
    Cuenca-Estrella, M
    Regadera, J
    González, M
    Díaz-Guerra, TM
    Rodríguez-Tudela, JL
    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2000, 38 (01) : 21 - 28
  • [2] Inhibitory effect of lactobacilli supernatants on biofilm and filamentation of Candida albicans, Candida tropicalis, and Candida parapsilosis
    Poon, Yeuklan
    Hui, Mamie
    FRONTIERS IN MICROBIOLOGY, 2023, 14
  • [3] Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae -: Inhibition with peptidomimetic inhibitors
    Pichová, I
    Pavlícková, L
    Dostál, J
    Dolejsí, E
    Hrusková-Heidingsfeldová, O
    Weber, J
    Ruml, T
    Soucek, M
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (09): : 2669 - 2677
  • [4] STRUCTURAL STUDIES OF MANNANS FROM CANDIDA ALBICANS (SEROTYPES A AND B) CANDIDA PARAPSILOSIS CANDIDA STELLATOIDEA AND CANDIDA TROPICALIS
    YU, RJ
    BISHOP, CT
    COOPER, FP
    HASENCLEVER, HF
    BLANK, F
    CANADIAN JOURNAL OF CHEMISTRY-BACK YEAR, 1967, 45 (19): : 2205 - +
  • [5] Synergistic Interactions between Pseudomonas aeruginosa and Candida albicans, Candida glabrata, Candida krusei, Candida parapsilosis as well as Candida tropicalis in the Formation of Polymicrobial Biofilms
    Andriana, Yenni
    Widodo, Agung Dwi Wahyu
    Arfijanto, Muhammad Vitanata
    JOURNAL OF PURE AND APPLIED MICROBIOLOGY, 2024, 18 (01): : 219 - 228
  • [6] INTRA-ABDOMINAL INFECTIONS WITH CANDIDA
    CALANDRA, T
    BILLE, J
    FRANCIOLI, P
    GLAUSER, MP
    SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT, 1985, : 45 - 45
  • [7] CELL-CONSTITUENT POLYAMINES IN CANDIDA SPECIES AND NEW BIOTYPING OF CANDIDA-ALBICANS, CANDIDA-TROPICALIS AND CANDIDA-PARAPSILOSIS STRAINS
    BEZJAK, V
    ALNAKIB, T
    CHANDY, R
    VERGHESE, R
    JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY, 1990, 28 (04): : 267 - 273
  • [8] Candida albicans commensalism in the gastrointestinal tract
    Neville, B. Anne
    d'Enfert, Christophe
    Bougnoux, Marie-Elisabeth
    FEMS YEAST RESEARCH, 2015, 15 (07)
  • [9] PATHOGENICITY OF CANDIDA-TROPICALIS AND CANDIDA-ALBICANS AFTER GASTROINTESTINAL INOCULATION IN MICE
    WINGARD, JR
    DICK, JD
    MERZ, WG
    SANDFORD, GR
    SARAL, R
    BURNS, WH
    INFECTION AND IMMUNITY, 1980, 29 (02) : 808 - 813
  • [10] EXTRACELLULAR ASPARTIC PROTEINASES FROM CANDIDA-ALBICANS, CANDIDA-TROPICALIS, AND CANDIDA-PARAPSILOSIS YEASTS DIFFER SUBSTANTIALLY IN THEIR SPECIFICITIES
    FUSEK, M
    SMITH, EA
    MONOD, M
    DUNN, BM
    FOUNDLING, SI
    BIOCHEMISTRY, 1994, 33 (32) : 9791 - 9799