Adipokines from adipose tissue and common variable immunodeficiency: Is there any association?

被引：1

作者：

Hassun, Luana Amorim ^{[1
]}

Ruggeri, Maria Luiza Ricarte ^{[1
]}

de Souza, Stefany Alvino ^{[1
]}

Rossato, Alice Mory ^{[1
]}

Chmieleski, Gabriela Souza ^{[1
]}

de Carvalho, Larissa Scarpini ^{[1
]}

Riccetto, Adriana Gut Lopes ^{[2
]}

Degasperi, Giovanna Rosa ^{[1
]}

机构：

[1] Pontifical Catholic Univ Campinas, Ctr Hlth Sci, Sch Med Sci, BR-13060904 Campinas, SP, Brazil

[2] Univ Estadual Campinas, Fac Med Sci, Dept Pediat, Pediat Allergy & Immunol,Unicamp, Campinas, SP, Brazil

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2023年 / 98卷 / 03期

关键词：

adiponectin; common variable immunodeficiency; leptin; ADIPONECTIN RECEPTORS; INSULIN-RESISTANCE; LEPTIN; OBESITY; INFLAMMATION; METABOLISM; LYMPHOPOIESIS; ACTIVATION;

D O I：

10.1111/sji.13257

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adiponectin and leptin are adipokines, secreted by white adipose tissue (WAT), which play an important role in energy homeostasis. Some evidence has shown that adipokine-producing adipose cells present in the bone marrow (BM) appear to exert an influence on hematopoiesis and B cell development. Common variable immunodeficiency (CVID) is one of the most common inborn errors of immunity in humans. In CVID, numerical and/or functional defects of B cells and their precursors result in hypogammaglobulinemia, usually Immunoglobulin (Ig) A and IgG. Manifestations of CVID include immunodeficiency, autoimmunity, inflammation and lymphoproliferation, resulting in a wide range of phenotypes. How adipokines interact and influence the pathophysiology of CVID is still unclear. In this review, we seek to summarize the aspects known so far concerning the interface between adipokines, B cells and CVID. More research is needed to fully understand these interactions; this knowledge is a potential avenue for the discovery of useful biomarkers and may provide new therapeutic targets for the treatment of patients with CVID and related diseases.

引用

页数：7

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