Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke

被引：5

作者：

Liu, Yuan ^{[1
]}

Qu, Juan ^{[2
]}

Xu, Junjie ^{[2
]}

Gu, Aiming ^{[2
]}

Deng, Dezhi ^{[2
]}

Jia, Xiaodan ^{[2
]}

Wang, Baoxiang ^{[2
]}

机构：

[1] Zhejiang Chinese Med Univ, Jiaxing Univ Master Degree Cultivat Base, Jiaxing, Peoples R China

[2] Jiaxing Univ, Hosp Jiaxing 1, Dept Neurol, Affiliated Hosp, Jiaxing, Peoples R China

来源：

FRONTIERS IN NEUROLOGY | 2023年 / 14卷

关键词：

ischemic stroke; trimethylamine-N-oxide; gut microbiota; trimethylamine; stroke; GUT MICROBIOTA; L-CARNITINE; METABOLISM; SUPPLEMENTATION; ASSOCIATION; THROMBOSIS; INCREASES;

D O I：

10.3389/fneur.2023.1156879

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly associated with the risk of stroke, as well as the severity and prognosis of stroke; however, this conclusion remains contentious. This article reviews the production of TMAO, TMAO's relationship with different etiological types of ischemic stroke, and the possibility of reducing TMAO levels to improve the prognosis of ischemic stroke.

引用

页数：8

共 69 条

[1] CLASSIFICATION OF SUBTYPE OF ACUTE ISCHEMIC STROKE - DEFINITIONS FOR USE IN A MULTICENTER CLINICAL-TRIAL
ADAMS, HP
BENDIXEN, BH
KAPPELLE, LJ
BILLER, J
LOVE, BB
GORDON, DL
MARSH, EE
KASE, CS
WOLF, PA
BABIKIAN, VL
LICATAGEHR, EE
ALLEN, N
BRASS, LM
FAYAD, PB
PAVALKIS, FJ
WEINBERGER, JM
TUHRIM, S
RUDOLPH, SH
HOROWITZ, DR
BITTON, A
MOHR, JP
SACCO, RL
CLAVIJO, M
ROSENBAUM, DM
SPARR, SA
KATZ, P
KLONOWSKI, E
CULEBRAS, A
CAREY, G
MARTIR, NI
FICARRA, C
HOGAN, EL
CARTER, T
GURECKI, P
MUNTZ, BK
RAMIREZLASSEPAS, M
TULLOCH, JW
QUINONES, MR
MENDEZ, M
ZHANG, SM
ALA, T
JOHNSTON, KC
ANDERSON, DC
TARREL, RM
NANCE, MA
BUDLIE, SR
DIERICH, M
HELGASON, CM
HIER, DB
SHAPIRO, RA
[J]. STROKE, 1993, 24 (01) : 35 - 41
[2] Associations between physical activity and trimethylamine N-oxide in those at risk of type 2 diabetes
Argyridou, Stavroula
Bernieh, Dennis
Henson, Joseph
Edwardson, Charlotte L.
Davies, Melanie J.
Khunti, Kamlesh
Suzuki, Toru
Yates, Thomas
[J]. BMJ OPEN DIABETES RESEARCH & CARE, 2020, 8 (02)
[3] High salt intake increases plasma trimethylamine N-oxide (TMAO) concentration and produces gut dysbiosis in rats
Bielinska, Klaudia
Radkowski, Marek
Grochowska, Marta
Perlejewski, Karol
Huc, Tomasz
Jaworska, Kinga
Motooka, Daisuke
Nakamura, Shota
Ufnal, Marcin
[J]. NUTRITION, 2018, 54 : 33 - 39
[4] Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
Chen, Ming-liang
Yi, Long
Zhang, Yong
Zhou, Xi
Ran, Li
Yang, Jining
Zhu, Jun-dong
Zhang, Qian-yong
Mi, Man-tian
[J]. MBIO, 2016, 7 (02):
[5] Effects of probiotic supplementation on serum trimethylamine-N-oxide level and gut microbiota composition in young males: a double-blinded randomized controlled trial
Chen, Si
Jiang, Ping-ping
Yu, Danxia
Liao, Gong-cheng
Wu, Shang-ling
Fang, Ai-ping
Chen, Pei-yan
Wang, Xiao-yan
Luo, Yun
Long, Jing-an
Zhong, Rong-huan
Liu, Zhao-yan
Li, Chun-lei
Zhang, Dao-ming
Zhu, Hui-lian
[J]. EUROPEAN JOURNAL OF NUTRITION, 2021, 60 (02) : 747 - 758
[6] TMAO as a Novel Predictor of Major Adverse Vascular Events and Recurrence in Patients with Large Artery Atherosclerotic Ischemic Stroke
Chen, Yan-Yan
Ye, Zu-Sen
Xia, Nian-Ge
Xu, Yun
[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2022, 28
[7] Association of Trimethylamine N-Oxide and Its Precursor With Cerebral Small Vessel Imaging Markers
Chen, Yiyi
Xu, Jie
Pan, Yuesong
Yan, Hongyi
Jing, Jing
Yang, Yingying
Wang, Xing
Wan, Huijuan
Gao, Ying
Han, Shangrong
Zhong, Xi
Liu, Chenhui
Pi, Jingtao
Li, Zhengyang
Luo, Biyang
Wang, Guangyao
Zhao, Yilong
Wang, Nan
Lin, Jinxi
Meng, Xia
Zhao, Xingquan
Liu, Liping
Li, Wei
Jiang, Yong
Li, Zixiao
Zhang, Xinmiao
Yang, Xiaomeng
Ji, Ruijun
Wang, Chunjuan
Li, Hao
Wang, Penglian
Zheng, Huaguang
Ji, Weizhong
Cai, Xueli
Wu, Songdi
Han, Xinsheng
Wang, Yongjun
Wang, Yilong
[J]. FRONTIERS IN NEUROLOGY, 2021, 12
[8] Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
Chidambaram, Saravana Babu
Essa, Musthafa Mohamed
Rathipriya, A. G.
Bishir, Muhammed
Ray, Bipul
Mahalakshmi, Arehally M.
Tousif, A. H.
Sakharkar, Meena K.
Kashyap, Rajpal Singh
Friedland, Robert P.
Monaghan, Tanya M.
[J]. PHARMACOLOGY & THERAPEUTICS, 2022, 231
[9] Exercise and associated dietary extremes impact on gut microbial diversity
Clarke, Siobhan F.
Murphy, Eileen F.
O'Sullivan, Orla
Lucey, Alice J.
Humphreys, Margaret
Hogan, Aileen
Hayes, Paula
O'Reilly, Maeve
Jeffery, Ian B.
Wood-Martin, Ruth
Kerins, David M.
Quigley, Eamonn
Ross, R. Paul
O'Toole, Paul W.
Molloy, Michael G.
Falvey, Eanna
Shanahan, Fergus
Cotter, Paul D.
[J]. GUT, 2014, 63 (12) : 1913 - 1920
[10] The association between TMAO, CMPF, and clinical outcomes in advanced chronic kidney disease: results from the European QUALity (EQUAL) Study
Dai, Lu
Massy, Ziad A.
Stenvinkel, Peter
Chesnaye, Nicholas C.
Larabi, Islam Amine
Alvarez, Jean Claude
Caskey, Fergus J.
Torino, Claudia
Porto, Gaetana
Szymczak, Maciej
Krajewska, Magdalena
Drechsler, Christiane
Wanner, Christoph
Jager, Kitty J.
Dekker, Friedo W.
Evenepoel, Pieter
Evans, Marie
[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2022, 116 (06) : 1842 - 1851

← 1 2 3 4 5 6 7 →