Development of Olive Oil Containing Phytosomal Nanocomplex for Improving Skin Delivery of Quercetin: Formulation Design Optimization, In Vitro and Ex Vivo Appraisals

被引:9
作者
Hendawy, Omnia M. [1 ]
Al-Sanea, Mohammad M. [2 ]
Elbargisy, Rehab Mohammed [3 ]
Rahman, Hidayat Ur [4 ]
Gomaa, Hesham A. M. [1 ]
Mohamed, Ahmed A. B. [5 ]
Ibrahim, Mohamed F. [6 ]
Kassem, Abdulsalam M. [6 ]
Elmowafy, Mohammed [3 ]
机构
[1] Jouf Univ, Coll Pharm, Dept Pharmacol, Sakaka 72341, Saudi Arabia
[2] Jouf Univ, Coll Pharm, Dept Pharmaceut Chem, Sakaka 72341, Saudi Arabia
[3] Jouf Univ, Coll Pharm, Dept Pharmaceut, Sakaka 72341, Saudi Arabia
[4] Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka 72341, Saudi Arabia
[5] Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt
[6] Al Azhar Univ, Fac Pharm Boys, Dept Pharmaceut & Pharmaceut Technol, Cairo 11651, Egypt
关键词
phytosomes; skin delivery; quercetin; olive oil; ORAL BIOAVAILABILITY; LIPID NANOPARTICLES; COMPLEX; PHOSPHOLIPIDS; PENETRATION; PERMEATION; CURCUMIN; PHOSPHATIDYLCHOLINE; LIPOSOMES; CORE;
D O I
10.3390/pharmaceutics15041124
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The objective of the current work was to fabricate, optimize and assess olive oil/phytosomal nanocarriers to improve quercetin skin delivery. Olive oil/phytosomal nanocarriers, prepared by a solvent evaporation/anti-solvent precipitation technique, were optimized using a Box-Behnken design, and the optimized formulation was appraised for in vitro physicochemical characteristics and stability. The optimized formulation was assessed for skin permeation and histological alterations. The optimized formulation (with an olive oil/PC ratio of 0.166, a QC/PC ratio of 1.95 and a surfactant concentration of 1.6%), and with a particle diameter of 206.7 nm, a zeta potential of -26.3 and an encapsulation efficiency of 85.3%, was selected using a Box-Behnken design. The optimized formulation showed better stability at ambient temperature when compared to refrigerating temperature (4 degrees C). The optimized formulation showed significantly higher skin permeation of quercetin when compared to an olive-oil/surfactant-free formulation and the control (similar to 1.3-fold and 1.9-fold, respectively). It also showed alteration to skin barriers without remarkable toxicity aspects. Conclusively, this study demonstrated the use of olive oil/phytosomal nanocarriers as potential carriers for quercetin-a natural bioactive agent-to improve its skin delivery.
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页数:22
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共 47 条
[41]   Development and optimization of sulforaphane-loaded nanostructured lipid carriers by the Box-Behnken design for improved oral efficacy against cancer: in vitro, ex vivo and in vivo assessments [J].
Soni, Kriti ;
Rizwanullah, Md. ;
Kohli, Kanchan .
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 46 :S15-S31
[42]   Development of Bimatoprost-Loaded Nano Spanlastic In-Situ Gel for Ophthalmic Drug Delivery: A Box-Behnken Optimization Approach with In Vitro and Ex Vivo Characterization [J].
Masareddy, Rajashree ;
Patted, Pradnya ;
Patil, Archana S. ;
Chougule, Krutuja R. .
JOURNAL OF PHARMACEUTICAL INNOVATION, 2025, 20 (04)
[43]   Design and Optimization of Quercetin-Loaded Polymeric Eudragit L-100 Nanoparticles for Anti-diabetic Activity with Improved Oral Delivery: In-Vitro and In-Vivo Evaluation [J].
Ahmad, Mohammad Zaki ;
Pathak, Kalyani ;
Das, Ratna Jyoti ;
Saikia, Riya ;
Sarma, Himangshu ;
Gogoi, Neelutpal ;
Gogoi, Urvashee ;
Das, Aparoop ;
Alasiri, Ali S. ;
Abdel-Wahab, Basel A. ;
Abdullah, M. M. .
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2023, 33 (08) :2411-2428
[44]   Design and Optimization of Quercetin-Loaded Polymeric Eudragit L-100 Nanoparticles for Anti-diabetic Activity with Improved Oral Delivery: In-Vitro and In-Vivo Evaluation [J].
Mohammad Zaki Ahmad ;
Kalyani Pathak ;
Ratna Jyoti Das ;
Riya Saikia ;
Himangshu Sarma ;
Neelutpal Gogoi ;
Urvashee Gogoi ;
Aparoop Das ;
Ali S. Alasiri ;
Basel A. Abdel-Wahab ;
M. M. Abdullah .
Journal of Inorganic and Organometallic Polymers and Materials, 2023, 33 :2411-2428
[45]   Acyl chitosan based self-nanoemulsifying drug delivery system of lipophilic drug with enhanced oral bioavailability and mucoadhesion: Formulation development, optimization and in vitro/in vivo characterization [J].
Sabale, Vidya ;
Girhepunje, Mrunali ;
Ingole, Ashwini ;
Warokar, Amol ;
Sawarkar, Krutika ;
Sabale, Prafulla .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 306
[46]   Central composite design (CCD) based formulation, optimization, in-vitro and ex-vivo characterization of 5-fluorouracil-loaded emulgel for enhanced dermal penetration and psoriasis management [J].
Parhi, Simran ;
Afrose, Naureen ;
Rajendran, Kavitha ;
Narayanasamy, Damodharan .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2025, 51 (03) :244-261
[47]   Development of Piperine-Loaded Soft Binary Ethosomal Gel to Improve Transdermal Delivery: Box-Bhekhen Design Optimization, Ex-Vivo Permeation, and Antimicrobial Evaluation [J].
Zafar, Ameeduzzafar ;
Yasir, Mohd ;
Khalid, Mohammad .
JOURNAL OF CLUSTER SCIENCE, 2024, 35 (01) :311-325