Effect of Frozen-Thawed Embryo Transfer on the Metabolism of Children in Early Childhood

被引:1
作者
Dong, Ze-Han [1 ,2 ]
Wu, Ting [1 ,2 ]
Zhang, Chen [1 ,2 ,3 ]
Su, Kai-Zhen [1 ,2 ]
Wu, Yan-Ting [3 ,4 ]
Huang, He-Feng [1 ,2 ,3 ,4 ,5 ]
机构
[1] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Sch Med, Shanghai 200030, Peoples R China
[2] Shanghai Key Lab Embryo Original Dis, Shanghai 200030, Peoples R China
[3] Fudan Univ, Obstet & Gynecol Hosp, Inst Reprod & Dev, Shanghai 200011, Peoples R China
[4] Chinese Acad Med Sci 2019RU056, Res Units Embryo Original Dis, Shanghai 200030, Peoples R China
[5] Zhejiang Univ, Womens Hosp,Sch Med, Dept Reprod Endocrinol, Key Lab Reprod Genet Minist Educ, Hangzhou 310058, Peoples R China
基金
上海市自然科学基金; 中国国家自然科学基金;
关键词
frozen-thawed embryo transfer; metabolomic; metabolite; BMI; SCFAs; bile acids; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTIVE TECHNOLOGIES; CHAIN FATTY-ACIDS; INSULIN-RESISTANCE; OVARIAN STIMULATION; FRESH; BORN; IVF; METABOLOMICS; ASSOCIATION;
D O I
10.3390/jcm12062322
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: As a routine procedure in assisted reproductive technology (ART), it is crucial to assess the safety of frozen and thawed embryo transfer (FET). We aimed to investigate the metabolic profile of children conceived through FET in their early childhood. Method: A total of 147 children between the age of 1.5 and 4 years old, conceived through FET or naturally conceived (NC), were recruited. A total of 89 children, 65 in the FET group and 24 in the NC group (matched with the FET group based on children's BMI) were included in the final statistical analysis of biochemical markers and metabolomics. Results: Children conceived through FET had a lower level of fasting insulin level and HORM-IR and a higher level of fasting glucose and APOE as compared to children naturally conceived. Metabolomics showed that there were 16 small differential metabolites, mainly including amino acids, carnitines, organic acids, butyric, and secondary bile acid between two groups, which enriched in Nitrogen metabolism, Butanoate metabolism, Phenylalanine metabolism, and D-Arginine and D-ornithine metabolism pathways. Conclusion: Although the FET group had a significantly higher level of APOE and fasting glucose, it cannot yet be considered that children in the FET group had an obvious disorder of glucose and lipid metabolism. However, the potentially more active intestinal flora and lower carnitine levels of children in the FET group suggested by metabolomics are worth further exploration.
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页数:12
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