Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications

被引：43

作者：

Czerwiec, Katarzyna ^{[1
]}

Zawrzykraj, Malgorzata ^{[1
]}

Deptula, Milena ^{[2
]}

Skoniecka, Aneta ^{[2
]}

Tyminska, Agata ^{[2
]}

Zielinski, Jacek ^{[3
]}

Kosinski, Adam ^{[1
]}

Pikula, Michal ^{[2
]}

机构：

[1] Med Univ Gdansk, Fac Med, Dept Anat, Div Clin Anat, PL-80211 Gdansk, Poland

[2] Med Univ Gdansk, Fac Med, Dept Anat, Div Embryol,Lab Tissue Engn & Regenerat Med, PL-80211 Gdansk, Poland

[3] Med Univ Gdansk, Dept Oncol Surg, PL-80214 Gdansk, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期

关键词：

AD-MSCs; fat tissue; stem cells; regenerative medicine; STEM-CELLS; BONE-MARROW; VASCULAR FRACTION; EXTRACELLULAR VESICLES; TISSUE; DIFFERENTIATION; MICRORNAS; THERAPY; DISEASE;

D O I：

10.3390/ijms24043888

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adipose-derived mesenchymal stromal cells (AD-MSCs) have been extensively studied in recent years. Their attractiveness is due to the ease of obtaining clinical material (fat tissue, lipoaspirate) and the relatively large number of AD-MSCs present in adipose tissue. In addition, AD-MSCs possess a high regenerative potential and immunomodulatory activities. Therefore, AD-MSCs have great potential in stem cell-based therapies in wound healing as well as in orthopedic, cardiovascular, or autoimmune diseases. There are many ongoing clinical trials on AD-MSC and in many cases their effectiveness has been proven. In this article, we present current knowledge about AD-MSCs based on our experience and other authors. We also demonstrate the application of AD-MSCs in selected pre-clinical models and clinical studies. Adipose-derived stromal cells can also be the pillar of the next generation of stem cells that will be chemically or genetically modified. Despite much research on these cells, there are still important and interesting areas to explore.

引用

页数：21

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