Grape juice reduces the effects of amyloid β aggregation phenotype and extends the longevity in Caenorhabditis elegans

Objectives: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of aggregated amyloid-beta (A beta) peptides. Several natural compounds have been proposed against this disease and grape products are among these. However, little is known about grape juice potential. Transgenic Caenorhabditis elegans (C. elegans) strains that express human A beta have been used as an in vivo model for AD. Methods: In this study, we have exposed CL2006 worms to nine different juices obtained from different cultivars. Results: Cora, Bordo, Isabel, Isabel Precoce, BRS-Magna, BRS-Rubea and BRS-Violeta juices improved the behavioral phenotype (paralysis) that is caused by A beta aggregation in the transgenic animals at the concentrations tested and no toxic effects were found. Some juices were also able to increase the worm's lifespan. We could not attribute lifespan increase and paralysis reduction with any specific compound found in the phytochemical analysis. Discussion: Our data indicate that the rich constitution of the juices is responsible for attenuating the phenotype caused by A beta aggregation in C. elegans.