Metaflammation in obesity and its therapeutic targeting

被引：55

作者：

Schleh, Michael W. ^{[1
]}

Caslin, Heather L. ^{[1
]}

Garcia, Jamie N. ^{[1
]}

Mashayekhi, Mona ^{[2
]}

Srivastava, Gitanjali ^{[2
,3
,4
,5
]}

Bradley, Anna B. ^{[2
,5
,6
]}

Hasty, Alyssa H. ^{[1
,6
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA

[2] Vanderbilt Univ Sch Med, Dept Med, Div Diabet Endocrinol & Metab, Nashville, TN 37232 USA

[3] Vanderbilt Univ Sch Med, Dept Pediat, Dept Pediat, Nashville, TN 37232 USA

[4] Vanderbilt Univ Sch Med, Dept Surg, Nashville, TN 37232 USA

[5] Vanderbilt Univ Sch Med, Vanderbilt Weight Loss Ctr, Nashville, TN 37204 USA

[6] VA Tennessee Valley Healthcare Syst, Nashville, TN 37212 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2023年 / 15卷 / 723期

关键词：

ADIPOSE-TISSUE MACROPHAGES; INNATE LYMPHOID-CELLS; DIET-INDUCED OBESITY; INDUCED WEIGHT-LOSS; INSULIN-RESISTANCE; T-CELLS; INFLAMMATORY MARKERS; CARDIOVASCULAR OUTCOMES; PROMOTE INFLAMMATION; SKELETAL-MUSCLE;

D O I：

10.1126/scitranslmed.adf9382

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity-associated inflammation is a systemic process that affects all metabolic organs. Prominent among these is adipose tissue, where cells of the innate and adaptive immune system are markedly changed in obesity, implicating these cells in a range of processes linking immune memory to metabolic regulation. Furthermore, weight loss and weight cycling have unexpected effects on adipose tissue immune populations. Here, we review the current literature on the roles of various immune cells in lean and obese adipose tissue. Within this context, we discuss pharmacological and nonpharmacological approaches to obesity treatment and their impact on systemic inflammation.

引用

页数：16

共 151 条

[1] Health Effects of Overweight and Obesity in 195 Countries over 25 Years [J].

Afshin, Ashkan ;

Forouzanfar, Mohammad H. ;

Reitsma, Marissa B. ;

Sur, Patrick ;

Estep, Kara ;

Lee, Alex ;

Marczak, Laurie ;

Mokdad, Ali H. ;

Moradi-Lakeh, Maziar ;

Naghavi, Mohsen ;

Salama, Joseph S. ;

Vos, Theo ;

Abate, Kalkidan H. ;

Abbafati, Cristiana ;

Ahmed, Muktar B. ;

Al-Aly, Ziyad ;

Alkerwi, Ala'a ;

Al-Raddadi, Rajaa ;

Amare, Azmeraw T. ;

Amberbir, Alemayehu ;

Amegah, Adeladza K. ;

Amini, Erfan ;

Amrock, Stephen M. ;

Anjana, Ranjit M. ;

Arnlov, Johan ;

Asayesh, Hamid ;

Banerjee, Amitava ;

Barac, Aleksandra ;

Baye, Estifanos ;

Bennett, Derrick A. ;

Beyene, Addisu S. ;

Biadgilign, Sibhatu ;

Biryukov, Stan ;

Bjertness, Espen ;

Boneya, Dube J. ;

Campos-Nonato, Ismael ;

Carrero, Juan J. ;

Cecilio, Pedro ;

Cercy, Kelly ;

Ciobanu, Liliana G. ;

Cornaby, Leslie ;

Damtew, Solomon A. ;

Dandona, Lalit ;

Dandona, Rakhi ;

Dharmaratne, Samath D. ;

Duncan, Bruce B. ;

Eshrati, Babak ;

Esteghamati, Alireza ;

Feigin, Valery L. ;

Fernandes, Joao C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (01) :13-27

[2] An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload [J].

Ameka, Magdalene K. ;

Beavers, William N. ;

Shaver, Ciara M. ;

Ware, Lorraine B. ;

Kerchberger, Vern Eric ;

Schoenfelt, Kelly Q. ;

Sun, Lili ;

Koyama, Tatsuki ;

Skaar, Eric P. ;

Becker, Lev ;

Hasty, Alyssa H. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (13)

[3] Weight Cycling Increases T-Cell Accumulation in Adipose Tissue and Impairs Systemic Glucose Tolerance [J].

Anderson, Emily K. ;

Gutierrez, Dario A. ;

Kennedy, Arion ;

Hasty, Alyssa H. .

DIABETES, 2013, 62 (09) :3180-3188

[4] Liraglutide in combination with metformin may improve the atherogenic lipid profile and decrease C-reactive protein level in statin treated obese patients with coronary artery disease and newly diagnosed type 2 diabetes: A randomized trial [J].

Anholm, Christian ;

Kumarathurai, Preman ;

Pedersen, Lene Rorholm ;

Samkani, Amirsalar ;

Walzem, Rosemary L. ;

Nielsen, Olav Wendelboe ;

Kristiansen, Ole Peter ;

Fenger, Mogens ;

Madsbad, Sten ;

Sajadieh, Ahmad ;

Haugaard, Steen Bendix .

ATHEROSCLEROSIS, 2019, 288 :60-66

[5] The biology of innate lymphoid cells [J].

Artis, David ;

Spits, Hergen .

NATURE, 2015, 517 (7534) :293-301

[6] Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis [J].

Askarpour, Moein ;

Khani, Dana ;

Sheikhi, Ali ;

Ghaedi, Ehsan ;

Alizadeh, Shahab .

OBESITY SURGERY, 2019, 29 (08) :2631-2647

[7] Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin [J].

Baeckdahl, Jesper ;

Franzen, Lovisa ;

Massier, Lucas ;

Li, Qian ;

Jalkanen, Jutta ;

Gao, Hui ;

Andersson, Alma ;

Bhalla, Nayanika ;

Thorell, Anders ;

Ryden, Mikael ;

Stahl, Patrik L. ;

Mejhert, Niklas .

CELL METABOLISM, 2021, 33 (09) :1869-+

[8] Body-Weight Fluctuations and Outcomes in Coronary Disease [J].

Bangalore, Sripal ;

Fayyad, Rana ;

Laskey, Rachel ;

DeMicco, David A. ;

Messerli, Franz H. ;

Waters, David D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (14) :1332-1340

[9] Effect of diet-induced energy deficit and body fat reduction on high-sensitive CRP and other inflammatory markers in obese subjects [J].

Belza, A. ;

Toubro, S. ;

Stender, S. ;

Astrup, A. .

INTERNATIONAL JOURNAL OF OBESITY, 2009, 33 (04) :456-464

[10] Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients [J].

Bertola, Adeline ;

Ciucci, Thomas ;

Rousseau, Deborah ;

Bourlier, Virginie ;

Duffaut, Carine ;

Bonnafous, Stephanie ;

Blin-Wakkach, Claudine ;

Anty, Rodolphe ;

Iannelli, Antonio ;

Gugenheim, Jean ;

Tran, Albert ;

Bouloumie, Anne ;

Gual, Philippe ;

Wakkach, Abdelilah .

DIABETES, 2012, 61 (09) :2238-2247

← 1 2 3 4 5 6 7 8 9 10 →