The effects of local anesthetics on cancer cells

被引：0
作者：
Humplikova, Simona [1 ,2 ]
Priscakova, Petra [1 ,2 ]
Repiska, Vanda [1 ,2 ]
机构：
[1] Comenius Univ, Inst Med Biol Genet & Clin Genet, Fac Med, Sasinkova 4, SK-81108 Bratislava, Slovakia
[2] Comenius Univ, Univ Hosp Bratislava, Inst Med Biol Genet & Clin Genet, Fac Med, Bratislava, Slovakia
来源：
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY | 2023年 / 124卷 / 12期
关键词：
local anesthetics; cancer cells; ROPIVACAINE; INTERLEUKIN-6; RECURRENCE; ACTIVATION; EXPRESSION; LIDOCAINE; SURVIVAL; INVASION; SURGERY; PAIN;
D O I：
10.4149/BLL_2023_141
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
During cancer surgery, the perioperative period is characterized by stress response and immunosuppression that can lead to further worsening of the disease and metastatic spread. Local anesthetics have antiproliferative, cytotoxic and antimetastatic effects on cancer cells in vitro. There is scientific evidence that local anesthetics possess anti-inflammatory effects, help to preserve normal immune function and reduce the possibility of metastatic spread. Anesthetic care affects pain, inflammation, and immunosuppression, which may have a great impact on the outcome of oncological patients. The use of local anesthetics during the perioperative period in oncological patients may have a beneficial effect on their survival and cancer recurrence. This article summarizes the effects of local anesthetics in vitro (Tab. 1, Fig. 1, Ref. 36). Text in PDF www.elis.sk
引用
收藏
页码：892 / 895
页数：4
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