Can Antidiabetic Medications Affect Telomere Length in Patients with Type 2 Diabetes? A Mini-Review

被引：1
作者：
Qin, Baoding [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol, Guangzhou, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 3, 600 Tianhe Rd Tianhe Dist, Guangzhou 510000, Guangdong, Peoples R China
来源：
DIABETES METABOLIC SYNDROME AND OBESITY | 2023年 / 16卷
关键词：
type; 2; diabetes; antidiabetic medications; telomere length; aging; IMPAIRED GLUCOSE-TOLERANCE; OXIDATIVE STRESS; METABOLIC DISEASE; SGLT2; INHIBITORS; METFORMIN; CELLS; HYPERGLYCEMIA; ASSOCIATION; SITAGLIPTIN; HALLMARKS;
D O I：
10.2147/DMSO.S428560
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The fight against aging is an eternal pursuit of humankind. The aging rate of patients with type 2 diabetes mellitus (T2DM) is higher than that of healthy individuals. Reducing the aging rate of patients with T2DM and extending their life expectancy are challenges that endocrinologists are eager to overcome. Many studies have shown that antidiabetic medications have potent anti-aging potential. Telomeres are repetitive DNA sequences located at the ends of chromosomes, and telomere shortening is a hallmark of aging. This review summarizes clinical trials that have explored the association between antidiabetic medications and telomere length (TL) in patients with T2DM and explore the mystery of delaying aging in patients with T2DM from the perspective of telomeres. Various antidiabetic medications may have different effects on TL in patients with T2DM. Metformin and sitagliptin may protect telomeres in patients with T2DM, while exogenous insulin may promote telomere shortening in patients with T2DM. The effect of acarbose and glyburide on TL in patients with T2DM is still uncertain due to the absence of evidence from longitudinal studies.
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收藏
页码：3739 / 3750
页数：12
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