Advances in the role of epigenetics in homocysteine-related diseases

被引：1
|
作者：
Wu, Chengyan [1 ]
Duan, Xulei [1 ]
Wang, Xuehui [1 ]
Wang, Libo [1 ]
机构：
[1] Xinxiang Med Univ, Affiliated Hosp 1, Xinxiang, Henan, Peoples R China
来源：
EPIGENOMICS | 2023年 / 15卷 / 15期
关键词：
DNA methylation; epigenetics; histone modifications; homocysteine; noncoding RNAs; SMOOTH-MUSCLE-CELLS; INDUCED OXIDATIVE STRESS; CYSTATHIONINE BETA-SYNTHASE; LEUKOCYTE TELOMERE LENGTH; NEURAL-TUBE DEFECTS; DNA METHYLATION; FOLIC-ACID; PLASMA HOMOCYSTEINE; GENE-EXPRESSION; INDUCED PROLIFERATION;
D O I：
10.2217/epi-2023-0207
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Homocysteine has a wide range of biological effects. However, the specific molecular mechanism of its pathogenicity is still unclear. The diseases induced by hyperhomocysteinemia (HHcy) are called homocysteine-related diseases. Clinical treatment of HHcy is mainly through folic acid and B-complex vitamins, which are not effective in reducing the associated end point events. Epigenetics is the alteration of heritable genes caused by DNA methylation, histone modification, noncoding RNAs and chromatin remodeling without altering the DNA sequence. In recent years the role of epigenetics in homocysteine-associated diseases has been gradually discovered. This article summarizes the latest evidence on the role of epigenetics in HHcy, providing new directions for its prevention and treatment.
引用
收藏
页码：769 / 795
页数：28
相关论文
共 50 条
  • [41] The role of epigenetics in cognitive ageing
    Mather, Karen A.
    Kwok, John B.
    Armstrong, Nicola
    Sachdev, Perminder S.
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2014, 29 (11) : 1162 - 1171
  • [42] Advances in the epigenetics of fibroblast biology and fibrotic diseases
    Ulukan, Burge
    Ozkaya, Yasemin Sila
    Zeybel, Mujdat
    CURRENT OPINION IN PHARMACOLOGY, 2019, 49 : 102 - 109
  • [43] Epigenetics and microRNAs in cardiovascular diseases
    Colpaert, Robin M. W.
    Calore, Martina
    GENOMICS, 2021, 113 (02) : 540 - 551
  • [44] Epigenetics and Autoimmune Thyroid Diseases
    Coppede, Fabio
    FRONTIERS IN ENDOCRINOLOGY, 2017, 8
  • [45] Exposome: Epigenetics and autoimmune diseases
    Danieli, Maria Giovanna
    Casciaro, Marco
    Paladini, Alberto
    Bartolucci, Martina
    Sordoni, Martina
    Shoenfeld, Yehuda
    Gangemi, Sebastiano
    AUTOIMMUNITY REVIEWS, 2024, 23 (06)
  • [46] Epigenetics in rare neurological diseases
    Roberts, Chris-Tiann
    Arezoumand, Khatereh Saei
    Shahib, Ashraf Kadar
    Davie, James R.
    Rastegar, Mojgan
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2024, 12
  • [47] Role of epigenetics andmiRNAsin orofacial clefts
    Garland, Michael A.
    Sun, Bo
    Zhang, Shuwen
    Reynolds, Kurt
    Ji, Yu
    Zhou, Chengji J.
    BIRTH DEFECTS RESEARCH, 2020, 112 (19): : 1635 - 1659
  • [48] Role of Epigenetics in Stem Cell Proliferation and Differentiation: Implications for Treating Neurodegenerative Diseases
    Srinageshwar, Bhairavi
    Maiti, Panchanan
    Dunbar, Gary L.
    Rossignol, Julien
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (02)
  • [49] Mitochondrial regulation of epigenetics and its role in human diseases
    Minocherhomji, Sheroy
    Tollefsbol, Trygve O.
    Singh, Keshav K.
    EPIGENETICS, 2012, 7 (04) : 326 - 334
  • [50] Recent advances in the epigenetics and genomics of asthma
    Koppelman, Gerard H.
    Nawijn, Martijn C.
    CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 11 (05) : 414 - 419
12345