Advances in the role of epigenetics in homocysteine-related diseases

被引：1
|
作者：
Wu, Chengyan [1 ]
Duan, Xulei [1 ]
Wang, Xuehui [1 ]
Wang, Libo [1 ]
机构：
[1] Xinxiang Med Univ, Affiliated Hosp 1, Xinxiang, Henan, Peoples R China
来源：
EPIGENOMICS | 2023年 / 15卷 / 15期
关键词：
DNA methylation; epigenetics; histone modifications; homocysteine; noncoding RNAs; SMOOTH-MUSCLE-CELLS; INDUCED OXIDATIVE STRESS; CYSTATHIONINE BETA-SYNTHASE; LEUKOCYTE TELOMERE LENGTH; NEURAL-TUBE DEFECTS; DNA METHYLATION; FOLIC-ACID; PLASMA HOMOCYSTEINE; GENE-EXPRESSION; INDUCED PROLIFERATION;
D O I：
10.2217/epi-2023-0207
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Homocysteine has a wide range of biological effects. However, the specific molecular mechanism of its pathogenicity is still unclear. The diseases induced by hyperhomocysteinemia (HHcy) are called homocysteine-related diseases. Clinical treatment of HHcy is mainly through folic acid and B-complex vitamins, which are not effective in reducing the associated end point events. Epigenetics is the alteration of heritable genes caused by DNA methylation, histone modification, noncoding RNAs and chromatin remodeling without altering the DNA sequence. In recent years the role of epigenetics in homocysteine-associated diseases has been gradually discovered. This article summarizes the latest evidence on the role of epigenetics in HHcy, providing new directions for its prevention and treatment.
引用
收藏
页码：769 / 795
页数：28
相关论文
共 50 条
  • [1] The role of epigenetics in aging and age-related diseases
    Calvanese, Vincenzo
    Lara, Ester
    Kahn, Arnold
    Fraga, Mario F.
    AGEING RESEARCH REVIEWS, 2009, 8 (04) : 268 - 276
  • [2] Gender: a primary homocysteine level-effecting factor for patients suffering homocysteine-related diseases
    Wang, Ai-Feng
    Zhang, Mei
    Lian-CaiWang
    Li, Qiao-Yan
    BIOMEDICAL RESEARCH-INDIA, 2017, 28 (01): : 353 - 356
  • [3] Homocysteine-related genes and attention in patients with schizophrenia and schizoaffective psychosis
    Golimbet, V. E.
    Lebedeva, I. S.
    Alfimova, M. V.
    Barkhatova, A. N.
    Lezheiko, T. V.
    Kolesina, N. Yu.
    Borozdina, S. A.
    Abramova, L. I.
    ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA, 2010, 110 (06) : 86 - 89
  • [4] Recent Advances in Epigenetics of Age-Related Kidney Diseases
    Liu, Feng
    Chen, Jiefang
    Li, Zhenqiong
    Meng, Xianfang
    GENES, 2022, 13 (05)
  • [5] The emerging Role of Epigenetics in Autoimmune Thyroid Diseases
    Wang, Bin
    Shao, Xiaoqing
    Song, Ronghua
    Xu, Donghua
    Zhang, Jin-an
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [6] Anti-inflammatory strategies for homocysteine-related cardiovascular disease
    Lin, Chih-Pei
    Chen, Yung-Hsiang
    Leu, Hsin-Bang
    Lin, Shing-Jong
    Chen, Yuh-Lien
    Huang, Song-Lih
    Chen, Jaw-Wen
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 : 3836 - 3845
  • [7] Histone modifications and their role in epigenetics of atopy and allergic diseases
    Alhamwe, Bilal Alaskhar
    Khalaila, Razi
    Wolf, Johanna
    von Buelow, Verena
    Harb, Hani
    Alhamdan, Fahd
    Hii, Charles S.
    Prescott, Susan L.
    Ferrante, Antonio
    Renz, Harald
    Garn, Holger
    Potaczek, Daniel P.
    ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 2018, 14
  • [8] Basics of Epigenetics and Role of Epigenetics in Diabetic Complications
    Yamunadevi, Andamuthu
    Pratibha, Ramani
    Rajmohan, Muthusamy
    Mahendraperumal, Sengottaiyan
    Ganapathy, Nalliappan
    JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2021, 13 (05): : 336 - 343
  • [9] Homocysteine and homocysteine-related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems
    Djuric, Dragan
    Jakovljevic, Vladimir
    Zivkovic, Vladimir
    Srejovic, Ivan
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2018, 96 (10) : 991 - 1003
  • [10] The critical importance of epigenetics in autoimmune-related skin diseases
    Lingyu Gao
    Qianjin Lu
    Frontiers of Medicine, 2023, 17 : 43 - 57
12345