Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids

被引：4
|
作者：
Serkov, S. A. [1 ]
Sigay, N. V. [1 ]
Kostikova, N. N. [1 ]
Tyurin, A. P. [2 ]
Kolotyrkina, N. G. [1 ]
Gazieva, G. A. [1 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky prosp, Moscow 119991, Russia
[2] Russian Acad Sci, M M Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, 16-10 ul Miklukho Maklaya, Moscow 117997, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 08期
关键词：
2-amino-1,3,4-thiadiazoles; 5-oxopyrrolidine-3-carboxylic acid; heterocyclic ensembles; itaconic acid; ANTIMICROBIAL ACTIVITY; BIOLOGICAL-ACTIVITY; DERIVATIVES;
D O I：
10.1007/s11172-023-3966-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new heterocyclic ensembles, derivatives of 5-oxo-1-(1,3,4-thiadiazol-2-yl)-pyrrolidine-3-carboxylic acid, was synthesized by heating 5-substituted 1,3,4-thiadiazol-2-amines and itaconic acid under solvent-free conditions or with the addition of acetic acid at 140-150 & DEG;C. The resulting acids can be used as building blocks in the synthesis of new potentially biologically active heterocyclic compounds.
引用
收藏
页码：1837 / 1843
页数：7
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