Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids

被引：4

作者：

Serkov, S. A. ^{[1
]}

Sigay, N. V. ^{[1
]}

Kostikova, N. N. ^{[1
]}

Tyurin, A. P. ^{[2
]}

Kolotyrkina, N. G. ^{[1
]}

Gazieva, G. A. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky prosp, Moscow 119991, Russia

[2] Russian Acad Sci, M M Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, 16-10 ul Miklukho Maklaya, Moscow 117997, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 08期

关键词：

2-amino-1,3,4-thiadiazoles; 5-oxopyrrolidine-3-carboxylic acid; heterocyclic ensembles; itaconic acid; ANTIMICROBIAL ACTIVITY; BIOLOGICAL-ACTIVITY; DERIVATIVES;

D O I：

10.1007/s11172-023-3966-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new heterocyclic ensembles, derivatives of 5-oxo-1-(1,3,4-thiadiazol-2-yl)-pyrrolidine-3-carboxylic acid, was synthesized by heating 5-substituted 1,3,4-thiadiazol-2-amines and itaconic acid under solvent-free conditions or with the addition of acetic acid at 140-150 & DEG;C. The resulting acids can be used as building blocks in the synthesis of new potentially biologically active heterocyclic compounds.

引用

页码：1837 / 1843

页数：7

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