Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases

被引：13
作者：
Jiang, Shufan [1 ,2 ]
Yang, Huili [1 ]
Li, Mingqing [1 ,3 ]
机构：
[1] Fudan Univ, Hosp Obstet & Gynecol, Lab Reprod Immunol, Shanghai 200080, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China
[3] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai 200080, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期
基金：
中国国家自然科学基金;
关键词：
lysophosphatidic acid; lysophosphatidic acid receptor; macrophage; inflammation; atherosclerosis; fibrosis; PROTEIN-COUPLED RECEPTOR; OVARIAN-CANCER CELLS; INDUCED LUNG INJURY; PROMOTES ATHEROSCLEROSIS; THERAPEUTIC TARGET; GROWTH-FACTOR; TGF-BETA; EXPRESSION; AUTOTAXIN; LPA;
D O I：
10.3390/ijms241512524
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and pathological processes in numerous cell biological functions, including cell migration, apoptosis, and proliferation. Macrophages are found in most human tissues and have multiple physiological and pathological functions. There is growing evidence that LPA signaling plays a significant role in the physiological function of macrophages and accelerates the development of diseases caused by macrophage dysfunction and inflammation, such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. In this review, we summarize the roles of LPA in macrophages, analyze numerous macrophage- and inflammation-associated diseases triggered by LPA, and discuss LPA-targeting therapeutic strategies.
引用
收藏
页数：19
相关论文
共 146 条
  • [41] Lpa2 Is a Negative Regulator of Both Dendritic Cell Activation and Murine Models of Allergic Lung Inflammation
    Emo, Jason
    Meednu, Nida
    Chapman, Timothy J.
    Rezaee, Fariba
    Balys, Marlene
    Randall, Troy
    Rangasamy, Tirumalai
    Georas, Steve N.
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 188 (08) : 3784 - 3790
  • [42] Recurrent perivascular inflammation induced by lipopolysaccharide (endotoxin) results in the formation of atheromatous lesions in vivo
    Engelmann, MG
    Redl, CV
    Nikol, S
    [J]. LABORATORY INVESTIGATION, 2004, 84 (04) : 425 - 432
  • [43] MicroRNA-21 is a unique signature associated with coronary plaque instability in humans by regulating matrix metalloproteinase-9 via reversion-inducing cysteine-rich protein with Kazal motifs
    Fan, Xuesong
    Wang, Enshi
    Wang, Xianyun
    Cong, Xiangfeng
    Chen, Xi
    [J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2014, 96 (02) : 242 - 249
  • [44] Fernandez Isis E, 2012, Proc Am Thorac Soc, V9, P111, DOI 10.1513/pats.201203-023AW
  • [45] Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis
    Fransson, Jennifer
    Gomez-Conde, Ana Isabel
    Romero-Imbroda, Jesus
    Fernandez, Oscar
    Leyva, Laura
    de Fonseca, Fernando Rodriguez
    Chun, Jerold
    Louapre, Celine
    Van-Evercooren, Anne Baron
    Zujovic, Violetta
    Estivill-Torrus, Guillermo
    Garcia-Diaz, Beatriz
    [J]. MOLECULAR NEUROBIOLOGY, 2021, 58 (02) : 470 - 482
  • [46] Lysophospholipid receptors
    Fukushima, N
    Ishii, I
    Contos, JJA
    Weiner, JA
    Chun, J
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2001, 41 : 507 - 534
  • [47] The Lysophosphatidic Acid Receptor LPA1 Promotes Epithelial Cell Apoptosis after Lung Injury
    Funke, Manuela
    Zhao, Zhenwen
    Xu, Yan
    Chun, Jerold
    Tager, Andrew M.
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2012, 46 (03) : 355 - 364
  • [48] Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages
    Gaire, Bhakta Prasad
    Lee, Chi-Ho
    Kim, Wondong
    Sapkota, Arjun
    Lee, Do Yup
    Choi, Ji Woong
    [J]. CELLS, 2020, 9 (08)
  • [49] Allergen provocation tests in respiratory research: building on 50 years of experience
    Gauvreau, Gail M.
    Davis, Beth E.
    Scadding, Guy
    Boulet, Louis-Philippe
    Bjermer, Leif
    Chaker, Adam
    Cockcroft, Donald W.
    Dahlen, Barbro
    Fokkens, Wyste
    Hellings, Peter
    Lazarinis, Nikolaos
    O'Byrne, Paul M.
    Tufvesson, Ellen
    Quirce, Santiago
    Van Maaren, Maurits
    de Jongh, Frans H.
    Diamant, Zuzana
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2022, 60 (02)
  • [50] Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge
    Georas, S. N.
    Berdyshev, E.
    Hubbard, W.
    Gorshkova, I. A.
    Usatyuk, P. V.
    Saatian, B.
    Myers, A. C.
    Williams, M. A.
    Xiao, H. Q.
    Liu, M.
    Natarajan, V.
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2007, 37 (03) : 311 - 322
12345678910