Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases

被引：13
作者：
Jiang, Shufan [1 ,2 ]
Yang, Huili [1 ]
Li, Mingqing [1 ,3 ]
机构：
[1] Fudan Univ, Hosp Obstet & Gynecol, Lab Reprod Immunol, Shanghai 200080, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China
[3] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai 200080, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期
基金：
中国国家自然科学基金;
关键词：
lysophosphatidic acid; lysophosphatidic acid receptor; macrophage; inflammation; atherosclerosis; fibrosis; PROTEIN-COUPLED RECEPTOR; OVARIAN-CANCER CELLS; INDUCED LUNG INJURY; PROMOTES ATHEROSCLEROSIS; THERAPEUTIC TARGET; GROWTH-FACTOR; TGF-BETA; EXPRESSION; AUTOTAXIN; LPA;
D O I：
10.3390/ijms241512524
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and pathological processes in numerous cell biological functions, including cell migration, apoptosis, and proliferation. Macrophages are found in most human tissues and have multiple physiological and pathological functions. There is growing evidence that LPA signaling plays a significant role in the physiological function of macrophages and accelerates the development of diseases caused by macrophage dysfunction and inflammation, such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. In this review, we summarize the roles of LPA in macrophages, analyze numerous macrophage- and inflammation-associated diseases triggered by LPA, and discuss LPA-targeting therapeutic strategies.
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页数：19
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共 146 条
  • [31] Adult Lysophosphatidic Acid Receptor 1-Deficient Rats with Hyperoxia-Induced Neonatal Chronic Lung Disease Are Protected against Lipopolysaccharide-Induced Acute Lung Injury
    Chen, Xueyu
    Walther, Frans J.
    Laghmani, El H.
    Hoogeboom, Annemarie M.
    Hogen-Esch, Anne C. B.
    van Ark, Ingrid
    Folkerts, Gert
    Wagenaar, Gerry T. M.
    [J]. FRONTIERS IN PHYSIOLOGY, 2017, 8
  • [32] Attenuation of LPS-induced cyclooxygenase-2 and inducible NO synthase expression by lysophosphatidic acid in macrophages
    Chien, Han-Yuan
    Lu, Chih-Shen
    Chuang, Kun-Han
    Kao, Pu-Hong
    Wu, Yuh-Lin
    [J]. INNATE IMMUNITY, 2015, 21 (06) : 635 - 646
  • [33] Lysophosphatidic acid up-regulates IL-10 production to inhibit TNF-α synthesis in Mφs stimulated with LPS
    Ciesielska, Anna
    Hromada-Judycka, Aneta
    Ziennlinska, Ewelina
    Kwiatkowska, Katarzyna
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2019, 106 (06) : 1285 - 1301
  • [34] Microglia Function in the Central Nervous System During Health and Neurodegeneration
    Colonna, Marco
    Butovsky, Oleg
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, VOL 35, 2017, 35 : 441 - 468
  • [35] Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
    Constantinescu, Cris S.
    Farooqi, Nasr
    O'Brien, Kate
    Gran, Bruno
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2011, 164 (04) : 1079 - 1106
  • [36] Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts
    David, Marion
    Wannecq, Estelle
    Descotes, Francoise
    Jansen, Silvia
    Deux, Blandine
    Ribeiro, Johnny
    Serre, Claire-Marie
    Gres, Sandra
    Bendriss-Vermare, Nathalie
    Bollen, Mathieu
    Saez, Simone
    Aoki, Junken
    Saulnier-Blache, Jean-Sebastien
    Clezardin, Philippe
    Peyruchaud, Olivier
    [J]. PLOS ONE, 2010, 5 (03):
  • [37] Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears
    Davies, Michael R.
    Lee, Lawrence
    Feeley, Brian T.
    Kim, Hubert T.
    Liu, Xuhui
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 2017, 35 (07) : 1539 - 1547
  • [38] LPA1 antagonist BMS-986020 changes collagen dynamics and exerts antifibrotic effects in vitro and in patients with idiopathic pulmonary fibrosis
    Decato, Benjamin E.
    Leeming, Diana Julie
    Sand, Jannie Marie Bulow
    Fischer, Aryeh
    Du, Shuyan
    Palmer, Scott M.
    Karsdal, Morten
    Luo, Yi
    Minnich, Anne
    [J]. RESPIRATORY RESEARCH, 2022, 23 (01)
  • [39] Cancer cell and macrophage cross-talk in the tumor microenvironment
    Dehnel, Nathalie
    Moral, Javier
    Namgaladzel, Dmitry
    Weigertl, Andreas
    Bruenet, Bernhard
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2017, 35 : 12 - 19
  • [40] Duong CQ, 2004, BBA-MOL CELL BIOL L, V1682, P112
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