Emerging Roles of Lysophosphatidic Acid in Macrophages and Inflammatory Diseases

被引：13
作者：
Jiang, Shufan [1 ,2 ]
Yang, Huili [1 ]
Li, Mingqing [1 ,3 ]
机构：
[1] Fudan Univ, Hosp Obstet & Gynecol, Lab Reprod Immunol, Shanghai 200080, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China
[3] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai 200080, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期
基金：
中国国家自然科学基金;
关键词：
lysophosphatidic acid; lysophosphatidic acid receptor; macrophage; inflammation; atherosclerosis; fibrosis; PROTEIN-COUPLED RECEPTOR; OVARIAN-CANCER CELLS; INDUCED LUNG INJURY; PROMOTES ATHEROSCLEROSIS; THERAPEUTIC TARGET; GROWTH-FACTOR; TGF-BETA; EXPRESSION; AUTOTAXIN; LPA;
D O I：
10.3390/ijms241512524
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and pathological processes in numerous cell biological functions, including cell migration, apoptosis, and proliferation. Macrophages are found in most human tissues and have multiple physiological and pathological functions. There is growing evidence that LPA signaling plays a significant role in the physiological function of macrophages and accelerates the development of diseases caused by macrophage dysfunction and inflammation, such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. In this review, we summarize the roles of LPA in macrophages, analyze numerous macrophage- and inflammation-associated diseases triggered by LPA, and discuss LPA-targeting therapeutic strategies.
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页数：19
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