Emerging Anticancer Therapeutic Modalities Brought by Gold Complexes: Overview and Perspectives

被引：6

作者：

Salmain, Michele ^{[1
]}

Bertrand, Benoit ^{[1
]}

机构：

[1] Sorbonne Univ, CNRS, UMR 8232, Inst Parisien Chim Mol IPCM, F-75005 Paris, France

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2023年 / 26卷 / 26期

关键词：

Gold; cancer; phototherapy; protein labeling; intracellular catalysis; CYCLOMETALATED GOLD(III) COMPLEXES; SELECTIVE FLUORESCENT-PROBE; N-HETEROCYCLIC CARBENES; PHOTODYNAMIC THERAPY; BODIPY DERIVATIVES; METAL-COMPLEXES; ESI-MS; CANCER; LIGAND; CATALYSIS;

D O I：

10.1002/ejic.202300340

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The medicinal chemistry of gold has experienced an exponential development since the 2000s. For long, the mechanisms of action of gold complexes have been limited to direct coordination of the gold ion or supramolecular interactions of the whole gold complex with biomolecules. In the recent years, other modes of action of gold-based drug candidates have emerged. Herein, we review these new modalities, including photo-induced cytotoxicity, selective protein modification and in cellulo catalysis.

引用

页数：20

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