Association Between Fatty Acid Intakes and Age-Related Macular Degeneration in a Japanese Population: JPHC-NEXT Eye Study

被引：4

作者：

Yasukawa, Tomoyo ^{[1
]}

Sasaki, Mariko ^{[1
,2
,3
,10
]}

Motomura, Kaoru ^{[1
]}

Yuki, Kenya ^{[1
]}

Kurihara, Toshihide ^{[1
]}

Tomita, Yohei ^{[1
]}

Mori, Kiwako ^{[1
]}

Ozawa, Nobuhiro ^{[1
]}

Ozawa, Yoko ^{[1
]}

Yamagishi, Kazumasa ^{[4
,5
,11
]}

Hanyuda, Akiko ^{[1
]}

Sawada, Norie ^{[6
]}

Tsubota, Kazuo ^{[1
]}

Tsugane, Shoichiro ^{[6
,7
]}

Iso, Hiroyasu ^{[4
,8
,9
]}

机构：

[1] Keio Univ, Dept Ophthalmol, Sch Med, Tokyo, Japan

[2] Tachikawa Hosp, Tokyo, Japan

[3] Natl Hosp Org Tokyo Med Ctr, Tokyo, Japan

[4] Univ Tsukuba, Fac Med, Dept Publ Hlth Med, Ibaraki, Japan

[5] Ibaraki Western Med Ctr, Ibaraki, Japan

[6] Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Epidemiol & Prevent Grp, Tokyo, Japan

[7] Natl Inst Biomed Innovat Hlth & Nutr, Natl Inst Hlth & Nutr, Tokyo, Japan

[8] Osaka Univ, Dept Social Med, Publ Hlth, Grad Sch Med, Osaka, Japan

[9] Natl Ctr Global Hlth & Med, Inst Global Hlth Policy Res, Bur Int Hlth Cooperat, Tokyo, Japan

[10] Keio Univ, Sch Med, Dept Ophthalmol, 35 Shinanomachi, Shinju ku, Tokyo 1608582, Japan

[11] Univ Tsukuba, Dept Publ Hlth Med, Fac Med, 1 1 1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

来源：

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY | 2023年 / 12卷 / 01期

基金：

日本学术振兴会;

关键词：

epidemiology; retina; age-related macular degeneration; fatty acids; dietary intake; DIETARY-FAT; DIAGNOSTIC-CRITERIA; DISEASE; HEALTH; RISK; PREVALENCE; PREVENTION; STROKE;

D O I：

10.1167/tvst.12.1.3

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To determine the associations between fatty acid intakes and the prevalence of age-related macular degeneration (AMD) under a population-based cross-sectional study. Methods: Residents of Chikusei City aged & GE;40 years underwent systemic and eye screening. AMD was graded according to a modified version of the Age-Related Eye Disease Study classification. Dietary intake was assessed using a food frequency questionnaire and was adjusted for total energy intake. Results: Altogether, 10,788 eyes of 5394 participants, 2116 men (mean [standard devia-tion (SD)] age, 62.4 [9.4] years) and 3278 women (60.6 [9.5] years), were included. The mean daily total fat intakes were 52.8 g and 59.0 g in men and women, respectively. After adjustments for potential confounders, saturated fatty acid (SFA) intake was inversely associated with the prevalence of any AMD in men (for each energy-adjusted 1-SD increase: odds ratio [OR], 0.86; 95% confidence interval [CI], 0.74-1.00). Significant trends were found for decreasing odds ratios of AMD with increasing SFA, monounsaturated fatty acid (MUFA), and polyunsaturated fatty acid (PUFA) intake (P for trend = 0.02, 0.04, and 0.04, respectively). In women, only a significant association was observed between the second quartile of linolenic acid intake and the prevalence of any AMD (OR, 0.78; 95% CI, 0.62-0.99). Conclusions: We found an inverse association of SFA intake and a weak inverse associ-ation of MUFA and PUFA intakes with the prevalence of any AMD in a Japanese popula-tion. Translational Relevance: Adequate fatty acid intake may be necessary to prevent or decelerate AMD.

引用

页数：14