Rutin alleviates colon lesions and regulates gut microbiota in diabetic mice

被引:19
|
作者
Cai, Cifeng [1 ]
Cheng, Wenwen [1 ]
Shi, Tiantian [1 ]
Liao, Yueling [1 ]
Zhou, Meiliang [2 ]
Liao, Zhiyong [1 ]
机构
[1] Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China
[2] Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China
关键词
AKKERMANSIA-MUCINIPHILA; OBESITY; MODEL; ASSOCIATION; METABOLISM; MODULATION; ABUNDANCE; DISEASES; GLUCOSE; HEALTH;
D O I
10.1038/s41598-023-31647-z
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Diabetes is a common metabolic disorder that has become a major health problem worldwide. In this study, we investigated the role of rutin in attenuating diabetes and preventing diabetes-related colon lesions in mice potentially through regulation of gut microbiota. The rutin from tartary buckwheat as analyzed by HPLC was administered intragastrically to diabetic mice, and then the biochemical parameters, overall community structure and composition of gut microbiota in diabetic mice were assayed. The results showed that rutin lowered serum glucose and improved serum total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride concentrations, tumor necrosis factor-& alpha;, interleukin-6, and serum insulin in diabetic mice. Notably, rutin obviously alleviated colon lesions in diabetic mice. Moreover, rutin also significantly regulated gut microbiota dysbiosis and enriched beneficial microbiota, such as Akkermansia (p < 0.05). Rutin selectively increased short-chain fatty acid producing bacteria, such as Alistipes (p < 0.05) and Roseburia (p < 0.05), and decreased the abundance of diabetes-related gut microbiota, such as Escherichia (p < 0.05) and Mucispirillum (p < 0.05). Our data suggested that rutin exerted an antidiabetic effect and alleviated colon lesions in diabetic mice possibly by regulating gut microbiota dysbiosis, which might be a potential mechanism through which rutin alleviates diabetes-related symptoms.
引用
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页数:13
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