The emerging role of fatty acid binding protein 5 (FABP5) in cancers

被引：26
|
作者：
Warren, William George [1 ]
Osborn, Myles [1 ]
Yates, Andy [1 ]
Wright, Karen [2 ]
O'Sullivan, Saoirse E. [1 ]
机构：
[1] Artelo Biosci, Solana Beach, CA 92075 USA
[2] Univ Lancaster, Fac Hlth & Med, Lancaster, England
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 07期
关键词：
cancer; tumour; fatty acid; lipid; fatty acid binding protein; FABP; MAMMARY-CARCINOMA GROWTH; LYMPH-NODE METASTASIS; RETINOIC-ACID; HEPATOCELLULAR-CARCINOMA; PROSTATE-CANCER; CERVICAL-CANCER; CELL-GROWTH; CRABP-II; MALIGNANT PROGRESSION; GEL-ELECTROPHORESIS;
D O I：
10.1016/j.drudis.2023.103628
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Fatty acid binding protein 5 (FABP5, or epidermal FABP) is an intracellular chaperone of fatty acid molecules that regulates lipid metabolism and cell growth. In patient -derived tumours, FABP5 expression is increased up to tenfold, often co-expressed with other cancer-related pro-teins. High tumoral FABP5 expression is associated with poor prognosis. FABP5 activates transcription factors (TFs) leading to increased expression of proteins involved in tumorigenesis. Genetic and pharmacological preclinical studies show that inhibiting FABP5 reduces protumoral markers, whereas elevation of FABP5 promotes tumour growth and spread. Thus, FABP5 might be a valid target for novel therapeutics. The evidence base is currently strongest for liver, prostate, breast, and brain cancers, and squamous cell carcinoma (SCC), which could represent relevant patient populations for any drug discovery programme.
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页数：15
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