Vancomycin-Loaded Porphyrinic MOF Nanoparticles for Killing Pathogenic Bacteria

The synthesis of functional antibacterial nanoplatformsfor killingpathogenic bacteria is urgent. Among them, combining traditional antibioticswith antimicrobial photodynamic therapy (PDT) is an attractive means.Here, we synthesized a multimodal antibacterial nanoplatform (denotedas Van/PCN) based on PCN-224 and vancomycin (Van). PCN-224 is a kindof photosensitizer-based nanoscale metal organic framework (pMOF),which not only possessed large surface area and many binding sitesfor loading Van but also had the ability to produce ROS under visiblelight irradiation. Van/PCN killed bacteria by Van and ROS, achievinga synergistic antibacterial effect. Since Gram-positive bacteria aresensitive to Van, this antibacterial nanoplatform has great potentialto treat bacterial infections caused by Gram-positive pathogens.