Recent advances on paper-based microfluidic devices for bioanalysis

被引：60
|
作者：
Silva-Neto, Habdias A. [1 ]
Arantes, Iana V. S. [2 ]
Ferreira, Andre L. [3 ]
do Nascimento, Guida H. M. [3 ]
Meloni, Gabriel N. [2 ]
de Araujo, William R. [3 ]
Paixa, Thiago R. L. C. [2 ,4 ]
Coltro, Wendell K. T. [1 ,4 ,5 ]
机构：
[1] Univ Fed Goias, Inst Quim, BR-74690900 Goiania, GO, Brazil
[2] Univ Sao Paulo, Dept Quim Fundamental, Inst Quim, BR-05508000 Sao Paulo, SP, Brazil
[3] Univ Estadual Campinas, Dept Quim Analit, Inst Quim, BR-13083970 Campinas, SP, Brazil
[4] Inst Nacl Ciencia & Tecnol Bioanalit, BR-13084971 Campinas, SP, Brazil
[5] Univ Fed Goias, Inst Quim, Campus Samambaia, BR-74690900 Goiania, GO, Brazil
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2023年 / 158卷
基金：
巴西圣保罗研究基金会;
关键词：
Portable analytical instrumentation; Cellulose; nitrocellulose materials; (bio)sensing; Wearable devices; Clinical applications; LATERAL FLOW ASSAY; DNA SENSOR; FABRICATION; BIOMARKERS; PLATFORM; POLYMER; PROTEIN; POINT; ACID;
D O I：
10.1016/j.trac.2022.116893
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Paper-based microfluidic devices have emerged as powerful platforms for bioanalysis offering advan-tages over other substrate materials including simpler fabrication protocols, compatibility with multi-purpose detectors, and global affordability. This review presents and discusses important information related to manufacturing methods, integrative sensing materials, the clinical relevance of biomarkers and bioanalysis. Examples of applications involving invasive and non-invasive samples, such as human serum, plasma, saliva, sweat, and urine are highlighted. Also, this review covers examples of (bio)sensing applications including the detection of viruses, microorganisms, neurodegenerative, cancer, diabetes, and allergic diseases. Lastly, the review summarizes recent examples of paper-based wearable devices and hybrid sensors dedicated to clinical applications and challenging points that can be carefully observed for the next generation of paper-based microfluidic sensors.
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页数：25
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