Ion homeostasis in diabetic kidney disease

被引：5
作者：
Hu, Hongtu [1 ,2 ]
Liang, Wei [1 ,2 ]
Ding, Guohua [1 ,2 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Div Nephrol, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China
[2] Key Clin Res Ctr Kidney Dis, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2024年 / 35卷 / 02期
基金：
中国国家自然科学基金;
关键词：
NA+-K+-ATPASE; SGLT2; INHIBITORS; CYTOSOLIC NA+; C-PEPTIDE; EXPRESSION; GLUCOSE; MAGNESIUM; ASSOCIATION; INCREASES; EXCHANGER;
D O I：
10.1016/j.tem.2023.09.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The complications of type 2 diabetes are a major global public health problem with high incidence and mortality, affecting almost all individuals with diabetes worldwide. Diabetic kidney disease (DKD) is one such primary complication and has become a leading cause of end-stage renal disease in patients with diabetes. Progression from diabetes to DKD is a complex process typically involving multiple mechanisms. Recent remarkable clinical benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in diabetes and DKD highlight the critical impact of renal ion homeostasis on disease progression. This review comprehensively examines the impact of ion homeostasis on the transition from diabetes to DKD, outlining possible therapeutic interventions and addressing the ongoing challenges in this rapidly developing field.
引用
收藏
页码：142 / 150
页数：9
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