Assessment of the risk of malignancy in Bethesda III thyroid nodules: a comprehensive review

被引：4

作者：

Rao, Karthik Nagaraja ^{[1
]}

Randolph, Gregory W. ^{[2
]}

Lopez, Fernando ^{[3
]}

Zafereo, Mark ^{[4
]}

Coca-Pelaz, Andres ^{[3
]}

Piazza, Cesare ^{[5
]}

Dange, Prajwal ^{[1
]}

Rodrigo, Juan Pablo ^{[3
]}

Stenman, Goeran ^{[6
]}

de Keizer, Bart ^{[7
]}

Nixon, Iain ^{[8
]}

Sinha, Shriyash ^{[1
]}

Leboulleux, Sophie ^{[9
]}

Maekitie, Antti A. ^{[10
,11
]}

Agaimy, Abbas ^{[12
,13
]}

Thompson, Lester ^{[14
]}

Ferlito, Alfio ^{[15
]}

机构：

[1] Sri Shankara Canc Hosp & Res Ctr, Dept Head & Neck Surg Oncol, Bangalore 560004, Karnataka, India

[2] Harvard Med Sch, Massachusetts Eye & Ear Infirm, Dept Otolaryngol Head & Neck Surg, Div Thyroid & Parathyroid Endocrine Surg, Boston, MA USA

[3] Univ Oviedo, Hosp Univ Cent Asturias, Dept Otolaryngol, CIBERONC,ISPA,IUOPA, Oviedo 33011, Spain

[4] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX USA

[5] ASST Spedali Civili Brescia, Unit Otorhinolaryngol Head & Neck Surg, Brescia, Italy

[6] Univ Gothenburg, Sahlgrenska Ctr Canc Res, Dept Pathol, Gothenburg, Sweden

[7] Univ Med Ctr Utrecht, Dept Nucl Med & Radiol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[8] Univ Edinburgh, Dept Surg & Otolaryngol Head & Neck Surg, Edinburgh EH3 9YL, Scotland

[9] Univ Geneva, Geneva Univ Hosp, Dept Endocrinol Diabetol Nutr & Therapeut Educ, Rue Gabrielle Perret Gentil, Geneva, Switzerland

[10] Univ Helsinki, Fac Med, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[11] Univ Helsinki, Res Program Syst Oncol, Helsinki, Finland

[12] Friedrich Alexander Univ Erlangen Nurnberg, Inst Pathol, Univ Hosp Erlangen, D-91054 Erlangen, Germany

[13] Comprehens Canc Ctr Erlangen EMN CCC ER EMN, D-91054 Erlangen, Germany

[14] Head & Neck Pathol Consultat, Woodland Hills, CA 91364 USA

[15] Coordinator Int Head & Neck Sci Grp, Padua, Italy

来源：

ENDOCRINE | 2024年 / 85卷 / 02期

关键词：

Thyroid neoplasms; Risk assessment; Molecular testing; Bethesda system; Artificial intelligence; PERFORMANCE; PREDICTOR; CANCER;

D O I：

10.1007/s12020-024-03737-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The increasing prevalence of thyroid cancer emphasizes the need for a thorough assessment of risk of malignancy in Bethesda III nodules. Various methods ranging commercial platforms of molecular genetic testing (including Afirma (R) GEC, Afirma (R) GSC, ThyroSeq (R) V3, RosettaGX (R), ThyGeNEXT (R)/ThyraMIR (R), ThyroidPRINT (R)) to radionuclide scans and ultrasonography have been investigated to provide a more nuanced comprehension of risk estimation. The integration of molecular studies and imaging techniques into clinical practice may provide clinicians with improved and personalized risk assessment. This integrated approach we feel may enable clinicians to carefully tailor interventions, thereby minimizing the likelihood of unnecessary thyroid surgeries and overall crafting the optimal treatment. By aligning with the evolving landscape of personalized healthcare, this comprehensive strategy ensures a patient-centric approach to thyroid nodule and thyroid cancer management.

引用

页码：473 / 492

页数：20

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