Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection

被引：1

作者：

Carey, Maureen ^{[1
]}

Arju, Tuhinur ^{[2
]}

Cotton, James A. ^{[3
]}

Alam, Masud ^{[2
]}

Kabir, Mamun ^{[2
]}

Faruque, Abu S. G. ^{[2
]}

Haque, Rashidul ^{[2
]}

Petri Jr, William A. ^{[1
]}

Gilchrist, Carol A. ^{[1
]}

机构：

[1] Univ Virginia, Dept Med, Carter Harrison Bldg,Crispell Ave, Charlottesville, VA 22908 USA

[2] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh

[3] Wellcome Sanger Inst, Cambridge, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 228卷 / 09期

基金：

英国惠康基金;

关键词：

Cryptosporidium; SNPs; genome sequences; parasite; DIARRHEA; SINGLE; ASSOCIATION; SEQUENCE;

D O I：

10.1093/infdis/jiad257

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptosporidium species are a major cause of diarrhea and associated with growth failure. There is currently only limited knowledge of the parasite's genomic variability. We report a genomic analysis of Cryptosporidium parvum isolated from Bangladeshi infants and reanalysis of sequences from the United Kingdom. Human isolates from both locations shared 154 variants not present in the cattle-derived reference genome, suggesting host-specific adaptation of the parasite. Remarkably 34.6% of single-nucleotide polymorphisms unique to human isolates were nonsynonymous and 8.2% of these were in secreted proteins. Linkage disequilibrium decay indicated frequent recombination. The genetic diversity of C. parvum has potential implications for vaccine and therapeutic design.

引用

页码：1292 / 1298

页数：7