Ultrasound Sonosensitizers for Tumor Sonodynamic Therapy and Imaging: A New Direction with Clinical Translation

被引：9
作者：
Liang, Yunlong [1 ]
Zhang, Mingzhen [2 ]
Zhang, Yujie [2 ]
Zhang, Mingxin [3 ]
机构：
[1] Shaanxi Univ Chinese Med, Clin Med Coll 2, Xianyang 712046, Peoples R China
[2] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Xian 710061, Peoples R China
[3] Xian Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Xian 710077, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 18期
基金：
中国国家自然科学基金; 美国国家科学基金会;
关键词：
sonodynamic therapy; sonosensitizers; clinical; integrated diagnosis and treatment; INTENSITY FOCUSED ULTRASOUND; PHOTODYNAMIC THERAPY; PHOTOTHERMAL THERAPY; PHASE-TRANSITION; BREAST-CANCER; NANOPARTICLES; CAVITATION; SONOLUMINESCENCE; CONVERSION; NANOSHEETS;
D O I：
10.3390/molecules28186484
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
With the rapid development of sonodynamic therapy (SDT), sonosensitizers have evolved from traditional treatments to comprehensive diagnostics and therapies. Sonosensitizers play a crucial role in the integration of ultrasound imaging (USI), X-ray computed tomography (CT), and magnetic resonance imaging (MRI) diagnostics while also playing a therapeutic role. This review was based on recent articles on multifunctional sonosensitizers that were used in SDT for the treatment of cancer and have the potential for clinical USI, CT, and MRI applications. Next, some of the shortcomings of the clinical examination and the results of sonosensitizers in animal imaging were described. Finally, this paper attempted to inform the future development of sonosensitizers in the field of integrative diagnostics and therapeutics and to point out current problems and prospects for their application.
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页数：20
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